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v0.1.3

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@PoHsuanLai PoHsuanLai released this 12 Apr 20:13
· 50 commits to master since this release
v0.1.3
d26cc3f

Critical fix for cross-trait LDSC

Fixed

  • LDSC cross-trait allele alignment. Z-scores were not flipped when A1 differed between traits, producing wrong-sign genetic covariance and ~10x inflated cross-trait intercepts. Diagonal (heritability) estimates were unaffected. All users running multi-trait LDSC should upgrade.
  • LDSC per-trait chi² filtering now matches R GenomicSEM's pre-filter-then-merge behavior. Cross-trait SNP counts now agree exactly with R.

Full Changelog: v0.1.2...v0.1.3

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