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MeRLin

MeRLin (Melanoma Resistance Lineage tracing) is a high-resolution lineage tracing system integrating single-cell RNA sequencing (scRNA-seq), RNA fluorescence in situ hybridization (RNA-FISH), and computational analyses to longitudinally track the clonal and transcriptional fates of melanoma cells under targeted therapy.

Requirement packages

  • R version 4.4.0
  • Seurat version 5.3.0
  • ClonoCluster version 0.0.1
  • inferCNV version 1.20.0
  • SCENIC version 1.3.1
  • SCopeLoomR version 0.13.0

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