Polygenic Risk Score Disease Trait

Polygenic Risk Score Disease/Trait

Here is the list of all traits in GWAS catalogs with more than 5 SNPs.

To use with the --prs function of TAPES.

This list can also be found in the ./acmg_db/gwas_terms2.txt from the TAPES repository.

We recommend the use of at least 20 SNPs for the PRS module.

Disease/Trait	Number of SNPs in GWAS catalog
1,5-anhydroglucitol levels	8
3-month functional outcome in ischaemic stroke (modified Rankin score)	54
ACPA-positive rheumatoid arthritis (smoking interaction)	15
AIDS	7
AIDS progression	8
Abdominal aortic aneurysm	16
Acne (severe)	37
Acute anterior uveitis (with or without ankylosing spondylitis)	14
Acute lymphoblastic leukemia (childhood)	62
Acute lymphoblastic leukemia in childhood (B cell precursor)	14
Adiponectin levels	6
Adolescent idiopathic scoliosis	28
Adult asthma	12
Advanced age-related macular degeneration	52
Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs)	6
Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs)	6
Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs)	12
Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs)	6
Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors)	6
Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin)	9
Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin)	7
Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel)	7
Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin)	7
Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel)	8
Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule)	7
Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU)	8
Affective disorder and suicide attempts	7
Age-related macular degeneration	94
Age-related macular degeneration (choroidal neovascularisation)	6
Age-related macular degeneration (geographic atrophy)	9
Aging (time to event)	8
Airflow obstruction	31
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)	54
Alcohol consumption (drinkers vs non-drinkers)	7
Alcohol consumption (drinks per week)	6
Alcohol dependence	55
Alcohol dependence (age at onset)	28
Alcohol use disorder (total score)	15
Alcoholic chronic pancreatitis	156
Allergic disease (asthma, hay fever or eczema)	169
Allergic rhinitis	79
Allergic rhinitis in non-asthmatics	7
Allergic sensitization	31
Allergy	25
Alopecia areata	44
Alzheimer's disease	146
Alzheimer's disease (late onset)	135
Alzheimer's disease (survival time)	7
Alzheimer's disease in APOE e4+ carriers	17
Alzheimer's disease in APOE e4- carriers	32
Alzheimer's disease or family history of Alzheimer's disease	13
Alzheimer's disease with language domain impairment	6
Alzheimer's disease with multiple cognitive domain impairments	9
Alzheimer's disease with no specific cognitive domain impairment	7
Alzheimer's disease with visuospatial domain impairment	9
Amyotrophic lateral sclerosis	86
Amyotrophic lateral sclerosis (sporadic)	10
Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals	6
Angiotensin-converting enzyme inhibitor intolerance	45
Ankle injury	42
Ankylosing spondylitis	106
Anorexia nervosa	8
Anthropometric traits	13
Anti-thyroid drug induced agranulocytosis	6
Antineutrophil cytoplasmic antibody-associated vasculitis	14
Anxiety disorder	6
Aortic root size	21
Arthritis (juvenile idiopathic)	7
Asparaginase hypersensitivity in acute lymphoblastic leukemia	9
Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time)	11
Asthma	275
Asthma (adult onset)	72
Asthma (childhood onset)	180
Asthma (moderate or severe)	27
Asthma (sex interaction)	6
Asthma and hay fever	21
Asthma exacerbations in inhaled corticosteroid treatment	16
Asthma onset (childhood vs adult)	55
Asthma or allergic disease (pleiotropy)	38
Atopic dermatitis	73
Atopic march	7
Atrial fibrillation	457
Attention deficit hyperactivity disorder	40
Attention deficit hyperactivity disorder or cannabis use	16
Atypical femoral fracture in phosphonate treatment	14
Autism	13
Autism spectrum disorder	54
Autism spectrum disorder or schizophrenia	300
Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)	60
Autism spectrum disorder-related traits	6
Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis)	11
BMI (adjusted for smoking behaviour)	143
BMI in non-smokers	104
BMI in smokers	30
BRCA1/2-negative high-risk breast cancer	19
Bacteremia	12
Barrett's esophagus	14
Barrett's esophagus or Esophageal adenocarcinoma	14
Basal cell carcinoma	65
Behcet's disease	20
Benign prostatic hyperplasia and lower urinary tract symptoms	23
Benign prostatic hyperplasia and lower urinary tract symptoms (prostate cancer excluded)	22
Biliary atresia	6
Bilirubin levels	30
Binge eating behaviour and bipolar disorder	7
Binge eating behaviour in bipolar disorder	6
Biochemical measures	17
Biomedical quantitative traits	6
Bipolar I disorder	63
Bipolar disorder	319
Bipolar disorder and eating disorder	10
Bipolar disorder and schizophrenia	116
Bipolar disorder with mood-incongruent psychosis	16
Birth weight	12
Bisphosphonate-associated atypical femoral fracture	37
Bladder cancer	32
Blond vs non-blond hair color	6
Blond vs. brown/black hair color	212
Blood pressure	93
Blood pressure measurement (cold pressor test)	7
Blood pressure measurement (high sodium and potassium intervention)	13
Blood pressure measurement (high sodium intervention)	11
Blood pressure measurement (low sodium intervention)	10
Body fat percentage	52
Body mass index	1270
Body mass index in physically active individuals	193
Bone mineral density	9
Bone mineral density (femoral neck)	6
Bone mineral density (hip)	30
Bone mineral density (spine)	37
Borderline personality disorder	28
Brain volume in infants (grey matter)	12
Brain volume in infants (white matter)	6
Breast Cancer in BRCA1 mutation carriers	15
Breast cancer	543
Breast cancer (early onset)	18
Breast cancer (estrogen-receptor negative)	73
Breast cancer (survival)	9
Breast cancer and/or colorectal cancer	18
Breast cancer in BRCA2 mutation carriers	6
Breast cancer specific mortality in breast cancer	47
Breast cancer specific mortality in estrogen receptor negative breast cancer	28
Breast cancer specific mortality in estrogen receptor positive breast cancer	22
Breast size	38
Bronchopulmonary dysplasia	26
Bronchopulmonary dysplasia in preterm infants	12
Brown vs. black hair color	55
Brown vs. non-brown hair color	8
C-reactive protein	14
C-reactive protein and white blood cell count	9
Caffeine consumption	10
Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level)	11
Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio)	31
Calcium levels	6
Cancer	43
Candidemia	8
Cannabis dependence	10
Carbamazepine-induced hyponatremia in epilepsy	7
Cardiac Troponin-T levels	18
Cardiovascular disease risk factors	20
Carpal tunnel syndrome	16
Celiac disease	99
Cervical cancer	38
Childhood ear infection	38
Chin dimples	46
Cholesterol, total	131
Chronic bronchitis and chronic obstructive pulmonary disease	11
Chronic central serous retinopathy	9
Chronic hepatitis B infection	23
Chronic kidney disease	65
Chronic lymphocytic leukemia	126
Chronic obstructive pulmonary disease	174
Chronotype	351
Circulating vasoactive peptide levels	7
Cisplatin-induced ototoxicity	20
Classic bladder exstrophy	25
Cleft lip with or without cleft palate	32
Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction)	8
Cleft palate	65
Clozapine-induced agranulocytosis	28
Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia	12
Coagulation factor levels	6
Coffee consumption	7
Cognitive ability	69
Cognitive ability (MTAG)	82
Colonoscopy-negative controls vs population controls	130
Colorectal adenoma (advanced)	30
Colorectal cancer	463
Colorectal cancer (SNP x SNP interaction)	7
Colorectal cancer (diet interaction)	13
Colorectal cancer or advanced adenoma	121
Colorectal or endometrial cancer	29
Complement C3 and C4 levels	10
Conduct disorder	12
Congenital heart disease (inherited effect)	10
Congenital heart disease (maternal effect)	20
Conotruncal heart defects	11
Conotruncal heart defects (inherited effects)	10
Conotruncal heart defects (maternal effects)	22
Corneal astigmatism	63
Corneal curvature	10
Coronary artery aneurysm in Kawasaki disease	22
Coronary artery disease	106
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease)	72
Coronary artery disease in type 1 diabetes	21
Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction)	8
Coronary heart disease	89
Corticobasal degeneration	8
Cough in response to angiotensin-converting enzyme inhibitor drugs	33
Craniofacial microsomia	13
Creatinine levels	9
Crohn's disease	385
Crohn's disease-related phenotypes	7
Cutaneous lupus erythematosus	7
Cutaneous psoriasis	10
Cutaneous squamous cell carcinoma	12
D-dimer levels	15
Daytime nap	7
Deep ovarian and/or rectovaginal disease with dense adhesions	10
Dehydroepiandrosterone sulphate levels	8
Delirium	27
Dementia with Lewy bodies	6
Depression	239
Depression and alcohol dependence	8
Diabetic kidney disease	58
Diabetic kidney disease in type 2 diabetes	9
Diabetic kidney disease in type 2 diabetes (ESRD vs. no ESRD)	14
Diabetic retinopathy	20
Diabetic retinopathy (all NPDR and PDR)	19
Diabetic retinopathy (moderate NPDR and PDR)	17
Dialysis-related mortality	26
Diastolic blood pressure	422
Diastolic blood pressure response to hydrochlorothiazide in hypertension	8
Dietary macronutrient intake	15
Differentiated thyroid cancer	9
Diffuse large B cell lymphoma	8
Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined)	10
Diisocyanate-induced asthma	179
Disease progression in age-related macular degeneration	62
Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer	12
Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN)	10
Drug-induced liver injury	6
Drug-induced liver injury (flucloxacillin)	17
Dupuytren's disease	41
Dysphagia	19
EGFR mutation-positive lung adenocarcinoma	6
Early onset atrial fibrillation	6
Early-onset Parkinson's disease	13
Eating disorders	6
Educational attainment	7
Educational attainment (college completion)	34
Educational attainment (years of education)	10
Electrocardiographic conduction measures	8
Electrocardiographic traits	21
Electroencephalogram traits	8
Emotional lability in attention deficit hyperactivity disorder	8
Emphysema-related traits	7
End-stage renal disease	7
Endometrial cancer	42
Endometrial cancer (Non-endometrioid histology)	7
Endometrial cancer (endometrioid histology)	32
Endometrial endometrioid carcinoma	7
Endometriosis	106
Endometriosis or endometrial cancer (pleiotropy)	8
Energy expenditure	11
Energy expenditure (24h)	9
Eosinophilic esophagitis	23
Eosinophilic esophagitis (pediatric)	14
Epilepsy	10
Epilepsy (remission after treatment)	7
Epilepsy and lamotrigine-induced maculopapular eruptions	27
Epithelial ovarian cancer	175
Erectile dysfunction and prostate cancer treatment	23
Erosive tooth wear (severe vs non-severe)	45
Esophageal adenocarcinoma	13
Esophageal cancer	13
Esophageal cancer (squamous cell)	7
Esophageal squamous cell carcinoma	10
Essential tremor	14
Estimated glomerular filtration rate	258
Eudaimonic well-being	21
Ewing sarcoma	7
Experiencing mood swings	69
Extremely high intelligence	26
Exudative age-related macular degeneration	7
Facial wrinkles	19
Familial lung adenocarcinoma	36
Familial lung cancer	20
Familial squamous cell lung carcinoma	68
Family history of Alzheimer's disease	36
Fasting blood glucose	15
Fasting plasma glucose	25
Febrile seizures	7
Febrile seizures (MMR vaccine-related)	10
Feeling fed-up	60
Feeling guilty	29
Feeling hurt	46
Feeling lonely	10
Feeling miserable	64
Feeling nervous	67
Feeling tense	33
Fibrinogen	15
Follicular lymphoma	14
Food addiction	6
Fractures	22
Freckles	11
Frontal fibrosing alopecia	37
Frontotemporal dementia	18
Frontotemporal dementia with GRN mutation	12
Fuchs's corneal dystrophy	8
Fulminant type 1 diabetes	9
Gait speed in old age	19
Gallbladder cancer	7
Gallstone disease	38
Gamma glutamyl transpeptidase	7
Gastric adenocarcinoma (histologically verified)	7
Gastric cancer	20
Gastritis	7
Gemcitabine-induced early high-grade neutropenia in pancreatic cancer	6
General cognitive ability	1248
Generalized epilepsy	10
Giant cell arteritis	8
Glaucoma	61
Glaucoma (primary angle closure)	22
Glaucoma (primary open-angle)	100
Glioblastoma	35
Glioblastoma (age-stratified)	20
Glioma	68
Glioma (high-grade)	6
Glomerular filtration rate in diabetes	7
Glycated hemoglobin levels	19
Glycemic traits	11
Gout	27
Graves' disease	36
Gut microbiota (bacterial taxa)	16
Gut microbiota (beta diversity)	15
Gut microbiota (functional units)	56
HDL cholesterol	334
HIV-1 control	10
HIV-1 susceptibility	6
Hand grip strength	23
Heart failure	16
Heart rate	7
Heart rate response to beta blockers (atenolol add-on therapy)	33
Heart rate response to beta blockers (atenolol monotherapy)	29
Heart rate response to exercise	32
Heart rate response to recovery post exercise	27
Height	302
Hematocrit	16
Hematological parameters	12
Hematology traits	6
Hemoglobin	11
Hemoglobin levels	11
Hemostatic factors and hematological phenotypes	7
Hepatitis	9
Hepatitis B	10
Hepatitis C (spontaneous viral clearance)	7
Hepatocellular carcinoma	9
Hepatocellular carcinoma in hepatitis B infection	11
Hepcidin levels	8
Heroin dependence	8
High-grade serous ovarian cancer	21
Hippocampal tail volume	7
Hippocampal tail volume (corrected for total hippocampal volume)	7
Hippocampal volume	13
Hirschsprung disease	17
Hodgkin's lymphoma	34
Hypersomnia (HLA-DQB1*06:02 negative)	6
Hypertension	39
Hypertriglyceridemia	24
Hypospadias	25
Hypothyroidism	45
Idiopathic dilated cardiomyopathy	44
Idiopathic inflammatory myopathy	7
Idiopathic membranous nephropathy	21
Idiopathic osteonecrosis of the femoral head	6
Idiopathic pulmonary fibrosis	14
IgA nephropathy	64
IgE grass sensitization	9
Immunoglobulin A	12
Immunoglobulin A vasculitis	7
Immunoglobulin light chain (AL) amyloidosis	10
Infantile hypertrophic pyloric stenosis	22
Inflammatory bowel disease	295
Inflammatory skin disease	15
Influenza A (H1N1) infection	10
Insomnia	397
Insomnia (caffeine-induced)	9
Insomnia symptoms (never/rarely vs. sometimes/usually)	49
Insomnia symptoms (never/rarely vs. usually)	55
Insulin resistance/response	14
Intelligence	560
Interferon alpha levels in systemic lupus erythematosus	8
Interstitial lung disease	18
Intracranial aneurysm	79
Intracranial volume	9
Intraocular pressure	49
Invasive epithelial ovarian cancer	19
Iron status biomarkers	20
Irritable bowel syndrome	11
Irritable mood	67
Ischemic stroke	27
Ischemic stroke (cardioembolic)	9
Ischemic stroke (large artery atherosclerosis)	7
JT interval (sulfonylurea treatment interaction)	14
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular)	31
Kawasaki disease	20
Knee osteoarthritis	35
LDL cholesterol	253
Large artery stroke	22
Laryngeal squamous cell carcinoma	6
Late-onset myasthenia gravis	19
Latent naming speed	7
Lateral ventricular volume in normal aging	7
Left ventricular obstructive tract defect (inherited effect)	15
Left ventricular obstructive tract defect (maternal effect)	9
Leprosy	40
Light vs. dark hair color	8
Lipid traits	18
Lipoprotein (a) levels	44
Lipoprotein phospholipase A2 activity in cardiovascular disease	16
Lipoprotein-associated phospholipase A2 activity and mass	14
Lipoprotein-associated phospholipase A2 activity change in response to statin therapy	7
Liver enzyme levels	11
Liver enzyme levels (alkaline phosphatase)	14
Liver enzyme levels (gamma-glutamyl transferase)	26
Longevity	32
Longevity (90 years and older)	10
Longitudinal alcohol consumption	6
Low high density lipoprotein cholesterol levels	11
Low white blood cell count (conditioned on rs2814778)	16
Low-grade serous and serous borderline ovarian cancer	12
Lower body strength	11
Lung adenocarcinoma	92
Lung cancer	182
Lung cancer in ever smokers	112
Lung cancer in never smokers	23
Lung function (FEV1)	23
Lung function (FVC)	32
Lung function (forced vital capacity)	7
Lupus nephritis in systemic lupus erythematosus	17
Lymphoma	13
Magnesium levels	28
Major depressive disorder	77
Major depressive disorder (broad)	9
Malaria	13
Male-pattern baldness	57
Maternal history of Alzheimer's disease	6
Mean arterial pressure	13
Mean corpuscular hemoglobin	18
Mean corpuscular hemoglobin concentration	10
Mean corpuscular volume	19
Mean platelet volume	51
Meconium ileus in cystic fibrosis	7
Melanoma	54
Memory dysfunction in frontotemporal lobe dementia	6
Menarche (age at onset)	82
Menarche and menopause (age at onset)	6
Menopause (age at onset)	120
Metabolic syndrome	33
Metabolic traits	11
Metabolite levels	18
Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event)	26
Migraine	144
Migraine - clinic-based	37
Migraine with aura	23
Migraine without aura	41
Mild influenza (H1N1) infection	18
Mitral valve prolapse	8
Moderate or severe diarrhoea in darapladib-treated cardiovascular disease (time to event)	7
Modic changes	10
Monoclonal gammopathy of undetermined significance	25
Morning person	213
Morning vs. evening chronotype	40
Mortality in heart failure	13
Mortality in sepsis	15
Mouth ulcers	94
Moyamoya disease	36
Mucinous adenocarcinoma in colorectal cancer	17
Mucinous ovarian carcinoma	13
Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma)	7
Multiple keratinocyte cancers	17
Multiple myeloma	43
Multiple myeloma (IgH translocation)	25
Multiple myeloma (hyperdiploidy)	14
Multiple sclerosis	310
Multiple sclerosis (OCB status)	12
Multiple system atrophy	22
Multiple system atrophy (pathologically confirmed)	16
Myasthenia gravis	9
Myocardial infarction	53
Myocardial infarction (early onset)	9
Myopia	50
Myopia (pathological)	15
Myositis	23
N-glycan levels	41
Narcolepsy	17
Nasal polyps	18
Nasopharyngeal carcinoma	31
Nephropathy	6
Neuroblastoma	10
Neurociticism	181
Neurocognitive impairment in HIV-1 infection (dichotomous)	9
Neuromyelitis optica	7
Neuromyelitis optica (AQP4-IgG-positive)	7
Neuroticism	523
Nodular sclerosis Hodgkin lymphoma	11
Non-cardia gastric cancer	8
Non-glioblastoma glioma	41
Non-melanoma skin cancer	82
Non-response to bupropion and depression	6
Non-small cell lung cancer (survival)	6
Nonalcoholic fatty liver disease	14
Nonsyndromic cleft lip with cleft palate	56
Nonsyndromic cleft lip with or without cleft palate	6
Obese vs. thin	14
Obesity	81
Obesity (early onset extreme)	24
Obesity (extreme)	26
Obesity without metabolic disease	13
Obesity-related traits	893
Obstetric antiphospholipid syndrome	15
Oral cavity and pharyngeal cancer	10
Oral cavity cancer	9
Orofacial clefts	63
Oropharynx cancer	17
Ossification of the posterior longitudinal ligament of the spine	8
Osteoarthritis	43
Osteoarthritis (hip)	67
Osteoarthritis (hospital diagnosed)	6
Osteoarthritis (self-reported)	29
Osteoarthritis of the hip (with total joint replacement)	6
Osteoarthritis of the hip or knee	32
Osteoarthritis of the hip or knee (hospital diagnosed)	8
Osteoarthritis of the knee (hospital diagnosed)	7
Osteoporosis-related phenotypes	6
Osteosarcoma	6
Ovarian cancer	56
Ovarian cancer in BRCA1 mutation carriers	9
Overall survival in osteosarcoma	9
Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin	10
P wave duration	20
P wave terminal force	12
PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia	11
PR interval	71
Paclitaxel-induced neuropathy	10
Paget's disease	13
Pancreatic cancer	101
Pancreatic ductal adenocarcinoma	9
Papillary thyroid cancer	9
Parkinson disease and lewy body pathology	10
Parkinson's disease	220
Peak insulin response	9
Pelvic organ prolapse	25
Pelvic organ prolapse (moderate/severe)	33
Pemphigus vulgaris	11
Pericardial adipose tissue adjusted for height and weight	7
Periodontal disease-related phenotypes	10
Periodontal microbiota	16
Periodontitis	18
Periodontitis (CDC/AAP)	28
Periodontitis (PAL4Q3)	18
Perioperative myocardial infarction in coronary artery bypass surgery	14
Peripheral arterial disease (traffic-related air pollution interaction)	154
Peripheral artery disease	9
Phospholipid levels (plasma)	17
Photic sneeze reflex	55
Placental abruption	9
Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid)	17
Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid)	10
Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid)	20
Plasma trimethylamine N-oxide levels	8
Platelet count	66
Pneumococcal bacteremia	9
Polycystic ovary syndrome	35
Polymyositis	8
Post-traumatic stress disorder	16
Posterior cortical atrophy and Alzheimer's disease	18
Pre-treatment pain in head and neck squamous cell carcinoma	9
Preeclampsia	18
Premature menopause in childhood cancer survivors	8
Presence of antiphospholipid antibodies	19
Prevalent atrial fibrillation	9
Primary biliary cholangitis	105
Primary biliary cirrhosis	47
Primary central nervous system lymphoma	7
Primary sclerosing cholangitis	49
Prion diseases	11
Progressive supranuclear palsy	16
Proliferative diabetic retinopathy (vs NPDR and no DR)	18
Proliferative diabetic retinopathy (vs no DR)	12
Prostate cancer	420
Prostate cancer (SNP x SNP interaction)	51
Prostate cancer (advanced)	18
Prostate cancer (early onset)	20
Protein C levels	15
Proteinuria and chronic kidney disease	9
Psoriasis	335
Psoriasis vulgaris	41
Psoriatic arthritis	57
Psychological distress	23
Psychosis and Alzheimer's disease	11
Psychosis in Alzheimer's disease	8
Pulmonary function	16
Pulse pressure	403
Putamen volume	10
Pyoderma gangrenosum in inflammatory bowel disease	7
QRS duration	132
QRS interval (sulfonylurea treatment interaction)	18
QT interval	97
QT interval (sulfonylurea treatment interaction)	12
Quantitative traits	33
Reading disability or specific language impairment (pleiotropy)	8
Red blood cell traits	20
Red vs. brown/black hair color	40
Refractive astigmatism	61
Renal cell carcinoma	37
Renal function-related traits (BUN)	15
Renal function-related traits (eGRFcrea)	10
Renal function-related traits (sCR)	9
Renal underexcretion gout	8
Residual cognition	9
Resistance to antihypertensive treatment in hypertension	6
Resistant hypertension	7
Response to SSRI (symptom remission)	8
Response to abacavir-containing treatment in HIV-1 infection (virologic failure)	27
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy)	11
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy)	13
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy)	9
Response to antidepressants (symptom remission)	11
Response to antineoplastic agents	9
Response to antipsychotic treatment	10
Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab)	13
Response to citalopram or escitalopram in depression	7
Response to citalopram treatment	7
Response to efavirenz-containing treatment in HIV 1 infection (virologic failure)	35
Response to fenofibrate (adiponectin levels)	12
Response to hepatitis C treatment	17
Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer	7
Response to lurasidone in schizophrenia	13
Response to platinum-based chemotherapy in non-small-cell lung cancer	6
Response to radiotherapy in prostate cancer (toxicity, decreased urine stream)	8
Response to radiotherapy in prostate cancer (toxicity, rectal bleeding)	6
Response to radiotherapy in prostate cancer (toxicity, urinary frequency)	11
Response to selective serotonin reuptake inhibitors in depression	8
Response to serotonin reuptake inhibitors in major depressive disorder	10
Response to statins (LDL cholesterol change)	8
Response to treatment for acute lymphoblastic leukemia	12
Resting heart rate	18
Resting metabolic rate	10
Restless legs syndrome	32
Rheumatoid arthritis	327
Rheumatoid arthritis (ACPA-negative)	8
Rheumatoid arthritis (ACPA-positive)	94
Sarcoidosis	10
Schizoaffective disorder-bipolar type	10
Schizophrenia	1690
Selective IgA deficiency	33
Self-reported risk-taking behaviour	26
Sense of smell	22
Serous borderline ovarian cancer	10
Serous invasive ovarian cancer	21
Serum 25-Hydroxyvitamin D levels	14
Serum bilirubin levels in metabolic syndrome	23
Serum prostate-specific antigen levels	6
Serum urate levels in chronic kidney disease	7
Serum urea levels	6
Serum uric acid levels	12
Severe influenza A (H1N1) infection	16
Severe malaria	16
Severe skin toxicity response to cetuximab in colorectal cancer	8
Sex hormone-binding globulin levels	25
Shingles	17
Sjögren's syndrome	52
Sleep duration	9
Sleep duration (long sleep)	8
Sleep duration (short sleep)	27
Small cell lung carcinoma	50
Small vessel stroke	9
Smoking behavior	31
Smoking cessation in chronic obstructive pulmonary disease	8
Snoring	42
Soluble ICAM-1	7
Spherical equivalent or myopia (age of diagnosis)	140
Sporadic neuroblastoma	9
Squamous cell carcinoma	18
Squamous cell lung carcinoma	101
Staphylococcus aureus infection	6
Staphylococcus aureus nasal carriage (intermittent)	7
Strenuous sports or other exercises	8
Stroke	31
Stroke (ischemic)	10
Subcortical brain region volumes	8
Sudden cardiac arrest	52
Suffering from nerves	12
Suicidal ideation	29
Suicide attempts	32
Suicide attempts in bipolar disorder	17
Suicide attempts in bipolar disorder or schizophrenia	18
Suicide attempts in major depressive disorder	21
Suicide attempts in major depressive disorder or bipolar disorder or schizophrenia	40
Suicide attempts in schizophrenia	20
Sulfasalazine-induced agranulocytosis	32
Supraventricular ectopy	6
Survival in colon cancer	12
Survival in microsatellite instability low/stable colorectal cancer	12
Survival in pancreatic cancer	61
Survival in rectal cancer	18
Systemic juvenile idiopathic arthritis	25
Systemic lupus erythematosus	658
Systemic lupus erythematosus and Systemic sclerosis	20
Systemic lupus erythematosus or rheumatoid arthritis	9
Systemic sclerosis	52
Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies)	26
Systolic blood pressure	680
Systolic blood pressure in sickle cell anemia	10
Systolic blood pressure response to hydrochlorothiazide in hypertension	10
Takayasu arteritis	69
Tanning	10
Temporomandibular joint disorder	7
Testicular germ cell cancer	6
Testicular germ cell tumor	126
Tetralogy of Fallot	6
Thiazide-induced adverse metabolic effects in hypertensive patients	59
Thionamide-induced agranulocytosis in Graves' disease	9
Thrombosis	12
Thyroid cancer	22
Thyroid peroxidase antibody positivity	11
Tinnitus in cisplatin-treated testicular cancer	10
Tonsillectomy	75
Total cholesterol levels	140
Total hippocampal volume	8
Tourette syndrome	31
Tourette's syndrome or obsessive-compulsive disorder	15
Treatment resistant depression	15
Triglyceride levels	15
Triglycerides	306
Triiodothyronine levels	6
Tuberculosis	63
Tumor biomarkers	11
Type 1 diabetes	143
Type 1 diabetes and autoimmune thyroid diseases	11
Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event)	9
Type 1 diabetes nephropathy	11
Type 2 diabetes	893
Type 2 diabetes (adjusted for BMI)	70
Type 2 diabetes and end-stage kidney disease	25
Type 2 diabetes and end-stage kidney disease in APOL1 risk genotype negative individuals	13
Type 2 diabetes nephropathy	12
Type 2 diabetes nephropathy including microalbuminuria	6
Ulcerative colitis	280
Urate levels	66
Urate levels in lean individuals	36
Urate levels in obese individuals	35
Urate levels in overweight individuals	43
Urgency urinary incontinence	6
Uric acid levels	24
Urinary bladder cancer	7
Urolithiasis	17
Uterine fibroid number (single vs multiple)	8
Uterine fibroids	62
Venous thromboembolism	42
Venous thromboembolism (SNP x SNP interaction)	37
Venous thromboembolism adjusted for sickle cell variant rs77121243-T	86
Vertical cup-disc ratio	9
Very long-chain saturated fatty acid levels (fatty acid 20:0)	21
Very long-chain saturated fatty acid levels (fatty acid 22:0)	11
Vigorous physical activity	8
Vitamin B12 levels	10
Vitamin D levels	16
Vitiligo	89
Waist circumference	10
Waist circumference adjusted for BMI in active individuals	235
Waist circumference adjusted for BMI in inactive individuals	14
Waist circumference adjusted for body mass index	260
Warfarin maintenance dose	20
Wegener's granulomatosis	6
Weight	35
White matter hyperintensities in ischemic stroke	8
White matter lesion progression	7
White matter lesion progression (adjusted for white matter lesion burden at baseline)	6
Wilms tumor	7
Worry too long after an embarrassing experience	34
Yu-Zhi constitution type in type 2 diabetes	11
middle facial morphology traits (quantitative measurement)	6
vWF and FVIII levels	11