PEN-ASSEMBLE v0.5.2

PEN-ASSEMBLE v0.5.2

IS110-family bridge recombinase design pipeline — 8-axis PenScore (pen-score v0.1.2).

Results summary (v0.5.1)

• 1,029 designs scored across 4 strategies (A–D)
• 16 designs beat IS621 verbatim lockpoint (PenScore > 0.929, pre-registered P1)
• 2 designs beat corrected IS621 lockpoint (PenScore > 0.957, v0.1.2 secondary)
• 5/5 pre-registered predictions PASS — "PUBLISH with strong claim"
• Top design: IS621_deimmunized_v2 (PenScore = 0.9673)

Dual catalog:

• catalog/pen_assemble_catalog.parquet — v0.5.0 frozen pre-registration record
• data/catalog_v0.5.1_current.parquet — v0.5.1 current (8-axis re-scored)

Install

pip install pen-assemble==v0.5.2

See README.md, RESCORING_v0.1.2.md, and DESIGN_PROVENANCE.md for full details.