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Adding dNdScv and expected mutated genomes to dev branch.

Still some details to fix related to running dNdScv with a custom definition of the reference transcripts but for now it can be run using the entire genes as a reference.

See #215 for a more detailed description.

FerriolCalvet and others added 18 commits October 2, 2024 14:45
- add all modules and scripts required for the run
missing:
- use custom RefCDS object
- provide covariates as file not as path value
- pull covariates file at the beginning and pass it through
missing:
- still using global ref. transcripts
missing:
- fix Rscript to store RefCDS also for non-mutated genes
- clean inputs and outputs to keep only the custom RefCDS object and the covariates
…extract gene strand for the expected mutation R script
- add output to createpanels subworkflow
- provide new input to expected mutrate and use it
- remove filtering of three genes for bladder
Addittional amend to the commit: Change output files for simplicity
additional updates in steps to provide the right inputs
pending:
- fix in samples' sex metadata
- still uncomplete RefCDS
- new parameter for the mutrisk_deepcsa script
- auto turn on or off based on last input

pending:
-final testing in non-bladder project
-fix pulling of file at the beginning or mounting file system
-make decision on whether sample definition for expmutrate and for creating groups are independent or not
-fix script when no mutations of gene-impact
- tmp fix: use global RefCDS object
- remove dependency from expmutrate
- check dndsout tables before writing avoid errors
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3 participants