Failure to expand macro with arguments containing comma

https://sourceforge.net/p/cppcheck/discussion/development/thread/73af296865
~~~c++
#define ADDER_S(a,b) a+b
#define ADDER(x) ADDER_S(x)
#define ARGUMENTS 1, 2

#define RUN  ADDER(ARGUMENTS)

int test(void) {
    //ADDER(ARGUMENTS);                     // Works
    RUN;                                    // Fails!!
    return 0;
}
~~~
It looks like a token `,,` is created somehow.