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Forepaw Electrical Stimulation: MD and MK Time-Dependence vs. BOLD-fMRI

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Learn about vigilant mode.

This dataset includes diffusion MRI and BOLD-fMRI data acquired from female Wistar rats (N = 10) subjected to forepaw electrical stimulation under ultra-high-field MRI.
The experiment was conducted to investigate how neural activity modulates mean diffusivity (MD) and mean kurtosis (MK) over multiple diffusion times, and how these changes relate to BOLD-fMRI activation.

License

Creative Commons Attribution 4.0 International (CC BY 4.0)

Citation

Hertanu, A. (2025). Forepaw electrical stimulation: MD and MK time-dependence vs. BOLD-fMRI [Data set].
Imaging Neuroscience.
Zenodo. https://doi.org/10.5281/zenodo.14793797

Related article: https://doi.org/10.1162/imag_a_00445

Source

https://doi.org/10.5281/zenodo.14793797
Publisher: Zenodo (Version v2, February 2025)
Associated Journal: Imaging Neuroscience (2025)
Contact: andreea.hertanu@weizmann.ac.il
Institution: Weizmann Institute of Science, Israel
Hardware: Bruker BioSpin 14.1 T MRI system with custom-built surface quadrature transceiver RF coil

Dataset Information

Category Details
Species Wistar rat (Rattus norvegicus)
Sex Female
Sample Size N = 10
Stimulation Paradigm Electrical forepaw stimulation
Scanner 14.1 T Bruker BioSpin MRI
RF Coil Home-built surface quadrature transceiver coil
Diffusion Times Five diffusion times (fast kurtosis protocol)
BOLD-fMRI TR 1 second
Stimulus Runs 5 functional runs (4 for rats 000002, 000003)
Data Format NIfTI, organized in BIDS-like structure
Total Size ~9.1 GB

Experimental Design

Each rat underwent repeated imaging sessions including diffusion-weighted imaging (DWI) and BOLD-fMRI under forepaw stimulation.
Both modalities included reversed EPI phase-encode direction acquisitions for distortion correction.

Diffusion-weighted Imaging (DWI)

  • 14 images at rest, 14 during stimulation
  • Repeated until 84 total volumes (excluding initial b0)
  • Acquired using fast kurtosis imaging (Hansen et al., 2016)

BOLD-fMRI

  • 28 images at rest, 28 during stimulation
  • Repeated until 336 total volumes per run
  • Temporal resolution = 1 s

Functional Runs

Each session consisted of five runs alternating rest and stimulation blocks.
Rats 000002 and 000003 completed four runs due to motion or physiological constraints.

Analysis Focus

The dataset supports multimodal analysis of:

  • Activity-driven microstructural changes via MD and MK modulations
  • Diffusion-time dependence of kurtosis metrics under activation
  • BOLD-dMRI correlations in somatosensory cortex

Region-of-interest analyses were conducted in the left hemisphere (contralateral to the right forepaw stimulation).
Signals were labeled as contralateral or ipsilateral based on expected somatosensory activation patterns.

Potential Applications

  • Joint modeling of BOLD and diffusion time-dependence
  • Validation of microstructural-functional coupling models
  • Exploration of neuronal vs. vascular origins of diffusion changes
  • Preclinical pipeline testing for multimodal rat fMRI

Keywords

Rat fMRI • Diffusion Kurtosis • MD Time-Dependence • Functional MRI • Forepaw Stimulation • BOLD • Fast Kurtosis Imaging • 14.1 Tesla MRI • Bruker BioSpin • Weizmann Institute

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