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Validation of Diffusion Tensor Imaging Measures of Nigrostriatal Neurons in Macaques

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This dataset provides in vivo diffusion MRI (DTI), together with companion PET, behavioral, and post‑mortem histology data from 16 non‑human primates (macaques) subjected to unilateral MPTP lesions of the nigrostriatal pathway. It supports validation of diffusion‑based markers of dopaminergic neuron integrity against gold‑standard histological and neurochemical measures.

License

Public domain (Dryad)

Citation

Shimony, J. S., Rutlin, J., Karimi, M., Tian, L., Snyder, A. Z., Loftin, S. K., Norris, S. A., & Perlmutter, J. S. (2019).
Validation of diffusion tensor imaging measures of nigrostriatal neurons in macaques [Data set]. Dryad.
https://doi.org/10.5061/dryad.2f8j75d

Primary article: PLOS ONE — https://doi.org/10.1371/journal.pone.0202201

Source

https://doi.org/10.5061/dryad.2f8j75d
Publisher: Dryad (Published Aug 14, 2019)
Affiliation: University of Washington School of Medicine

Dataset Information

Category Details
Species Rhesus macaque / NHP (macaques)
Subjects 16 animals
Model Unilateral carotid artery infusion of MPTP (dopaminergic neurotoxin)
Modalities Diffusion MRI (DTI), PET (three presynaptic ligands), video-based motor ratings, histology (TH) & neurochemistry (striatal dopamine)
Outcome Measures DTI metrics of the nigrostriatal tract, PET uptake, striatal TH‑positive fiber density, nigral TH‑positive cell counts, striatal dopamine concentration
Key Finding (from abstract) DTI metrics correlate with MPTP dose, nigral TH cell counts, and striatal TH fiber density; PET/terminal field measures show floor effects after >50% nigral loss where DTI continues to correlate
Data Format DICOM archives (*.tar) plus study notes (MonkeyDataSharing.txt)
Total Size ~22.6 GB

Experimental Overview

  • Design: Each animal received unilateral MPTP to induce varying degrees of nigrostriatal injury.
  • Imaging: Pre/post DTI and PET with three presynaptic radioligands; blinded motor ratings.
  • Endpoints: Post‑mortem quantification of striatal dopamine, TH‑positive striatal fibers, and TH‑positive nigral cell bodies.
  • Analysis: Diffusion measures along the nigrostriatal tract compared to PET and histology across injury severities.

Suggested Uses

  • Validation of tract‑specific diffusion biomarkers for dopaminergic neurodegeneration.
  • Method development for nigrostriatal tractography and ROI quantification in NHPs.
  • Comparative evaluation of DTI vs PET sensitivity across lesion severity.
  • Benchmarking pipelines for DICOM→NIfTI conversion and diffusion processing in NHP datasets.

Notes

  • Dryad distribution provides raw DICOM per subject; users should convert to NIfTI (e.g., dcm2niix) and perform species‑appropriate preprocessing.
  • Tract definitions (midbrain↔striatum) and ROI placement should follow the primary article’s methods to reproduce correlations.

Keywords

Diffusion MRI • DTI • Nigrostriatal • MPTP • Macaque • Dopamine • TH immunostaining • PET • Parkinson’s disease • Non‑human primate • Validation

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