If I quit Safari with any open windows/tabs and then restart with Javascript Blocker enabled,
Safari 8.0 (stock Yosemite 10.10 browser, with Adblock Plus, ClickToFlash and Javascript Blocker extensions) hangs at startup.
CPU is pegged at 100% and UI is beachballed and unresponsive.
It APPEARS that Javascript Blocker is attempting to pop up some whacky report or whacky dialog.

I'll try to add an "Activity Monitor" generated sampled backtrace once I work out how github attachments work