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0.1.5-alpha

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@dancooke dancooke released this 08 Nov 19:53
· 3698 commits to master since this release

This release contains numerous bug fixes and enhancements:

Bug fixes

  • Fixes bug in assembler which could cause segmentation faults.
  • Fixes bug in haplotype generation which could cause exceptions.
  • Fixes bad VCF genotype output for somatic variants (e.g. 2|0).
  • Prevents spurious "Not a BGZF file" warning.
  • Building fixes.

Key improvements

  • Many improvements have been made to the cancer calling model. In particular specificity has been significantly improved. A model posterior is now reported by default which can be used to hard filter calls. Runtime has been improved, but still needs much work.
  • The assembler can now selectively extracts bubbles of a minimum weight, increasing both specificity and sensitivity.

Other changes

  • Command line options have been added for the new features.
  • The command line options --debug and --trace can now take arguments (file paths) to write the respective logs to.
  • Downsampling limits have been increased.
  • Some other command line option names and default values have changed.