Had a bit of a shock when the mox webadmin / webaccount overwrote my domains.conf stripping all comments - I had temporarily commented out the somewhat meticulous DKIM : Selectors config with its long intricate filenames, to relay everything through SES, and after some web-based operations (adding a new mail account I think) found all the commented section stripped and all my DKIM configuration from quickstart gone.
Had to restore a backup of the entire server from a few days ago to get it back.
Maybe just a warning comment at the top of domains.conf:
# WARNING: the web admin will automatically change this file, stripping comments; keep a backup if needed