Amino acid level redux for genotypes to determine single amino acid mismatch identity #355
Description
We've been looking at NGS typing data where there is ambiguity due to inability to phase exons.
A lot of NGS typing strategies for DPB1 include multiple amplicons, resulting in ambiguity at the two-field level.
We would like a pyARD function to test if all possible genotypes in this GL string would translate into expressed proteins with the same set of amino acids (not considering phasing of amino acids within alleles).
This function would test a GL string to determine if it is at the level of resolution that would be sufficient to compute single amino acid mismatches.
For example the set of single amino acid mismatches against a donor with this ambiguous genotype would not differ regardless of which two-field genotype the donor turned out to have.
HLA-DPB1*04:01:01:06/939:01/126:01+HLA-DPB1*04:02:01:02/105:01/665:01
This idea is somewhat analogous to the SBT Ambigs, except for amino acids instead. https://www.ebi.ac.uk/ipd/imgt/hla/ambiguity/