Add species-weighted metrics for HYE quant modules so that quant accuracy metric is not dominated by most abundant human precursors #923
rodvrees
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Feature request
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In the current modules, the median and mean log2FCs are calculated globally, i.e. across all precursors. Because in the current HYE samples from the Van Puyvelde et al. dataset (data from which is used for almost all current modules), human precursors are vastly more represented in the sample mixes, the median and mean log2FCs will be predominantly dominated by the error on human precursors, and less by others. This is why it is important to also have metrics that are weighted equally for each species, because, if anything, the quant accuracy on the lower abundant species' precursors is more important.
The user ideally should be able to choose whether to visualize the overall mean/median log2FC, or a species-weighted metric.
Work on the implementation on this is already underway (actually it's finished), but implementing this on the already existing modules requires the recalculation (i.e. resubmission) of all currently existing datapoints, which is not something we have automated, at the moment.
Once we have automated resubmission of existing datapoints, we can implement the new toggle.
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