In a simple EPUB3 with scripting (Javascript), the button click touch event does not work in R2 Reader on Android. This can be seen with the attached EPUB3 which implements simple addition, where it is impossible to click the button (the different pages try variations of the Javascript code, but the button touch event never works). However, by pressing the Return or Next Tab key on the Android touch keyboard it is possible to confirm that the addition gets correctly executed, so the issue is solely that touch input has been blocked (as can also been seen with trying to touch the second input text box, in addition to the click button).
The same EPUB3 (button-click-epub3.epub) works fine in the R2 Reader desktop app (with mouse input) and R2 Reader iOS app (with touch input).
Version and Device Details:
R2 Reader Android App version: 2.0.0
GitHub Tag: V2.0.0-beta.4
Android mobile device: Moto G3 running Android 6.0.1.
Note: I had to rename the .epub as a .zip to upload it (you may unpack it or rename it as .epub and then look at the code of individual XHTML pages, which is just basic Javascript).
button-click-epub3.zip