Starting out with a default create-react-app and trying to server it via webxdc-dev run http://localhost:3000 gives me the following error Invalid manifest.toml, please check the format, and then webxdc-dev exits.
It would be more helpful if it could tell the difference between a parse error and a 404, or even just do a warning and continue as it does with serving directory of static files without a manifest.toml.