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BioRouter v1.60.0

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@Broccolito Broccolito released this 13 Apr 03:27
v1.60.0
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BioRouter v1.60.0 Release Notes

Release Date: April 2026
Repository: github.com/BaranziniLab/BioRouter

Downloads

This release includes native installers for all major platforms and the BioRouter CLI binary for macOS — all available in the same GitHub Release:

GUI App

Platform File Install
macOS (Apple Silicon / M chip) BioRouter-1.60.0-arm64.dmg Open DMG and drag BioRouter.app to /Applications
macOS (Intel) BioRouter-1.60.0-x64.dmg Open DMG and drag BioRouter.app to /Applications
Windows (x64) BioRouter-win32-x64-1.60.0.zip Unzip and run BioRouter.exe
Linux Ubuntu / Pop!_OS (x64) biorouter_1.60.0_amd64.deb sudo dpkg -i biorouter_1.60.0_amd64.deb
Linux Fedora / RHEL (x64) BioRouter-1.60.0-1.x86_64.rpm sudo rpm -i BioRouter-1.60.0-1.x86_64.rpm

CLI Binary (macOS only)

Platform File Usage
macOS (Apple Silicon) biorouter-cli-macos-arm64 chmod +x biorouter-cli-macos-arm64 && ./biorouter-cli-macos-arm64
macOS (Intel) biorouter-cli-macos-x64 chmod +x biorouter-cli-macos-x64 && ./biorouter-cli-macos-x64

What's New

Expanded Model Support — All Providers Updated

Comprehensive model list update across every provider, verified against live APIs.

Amazon Bedrock (UCSF MuleSoft Proxy)

  • Default model updated to us.anthropic.claude-sonnet-4-6
  • Confirmed available: Claude Sonnet 4.6, Claude Sonnet 4.0, Claude Opus 4.1, Claude Opus 4.5
  • Removed models the UCSF proxy IAM policy does not permit — no more silent auth failures

Azure OpenAI (UCSF Unified API)

  • Default model updated to gpt-5.2-2025-12-11
  • Confirmed available: GPT-5.2, GPT-4.1, GPT-4.1-mini, GPT-4o, o1, o3-mini, o4-mini
  • API version bumped to 2025-01-01-preview — unlocks o1/o3-mini/o4-mini reasoning models

Anthropic (Direct API)

  • Default updated to claude-sonnet-4-6
  • Added Claude 4.6 family: claude-opus-4-6, claude-sonnet-4-6

OpenAI (Direct API)

  • Default updated to gpt-5.2
  • Added full GPT-5 series: gpt-5, gpt-5.1, gpt-5.1-codex, gpt-5.2, gpt-5.4
  • Added o3-mini; updated context window sizes throughout

Google (Direct API)

  • Added Gemini 3 series: gemini-3-flash-preview, gemini-3-pro-preview, gemini-3-pro-image-preview
  • Default remains gemini-2.5-pro

GPT-5.4 Support via OpenAI Responses API

GPT-5.4 requires OpenAI's /v1/responses endpoint rather than /v1/chat/completions. BioRouter now automatically routes requests to the correct endpoint based on the model — users simply select gpt-5.4 and everything works transparently. Full tool use and streaming are supported.

Amazon Bedrock Endpoint Normalization

Users setting AWS_ENDPOINT_URL_BEDROCK (the intuitive short form) previously got a silent authentication failure because the AWS SDK for Rust expects AWS_ENDPOINT_URL_BEDROCK_RUNTIME. BioRouter now auto-promotes the short form to the correct key before the SDK initializes — both names work transparently.

Session History Fix (upgrade from pre-v1.50.0)

Users upgrading from older versions saw "Error Loading Sessions" due to a column rename (recipe_json → workflow_json) that lacked a database migration. Migration v7 now runs automatically on startup and safely renames the columns on existing databases, restoring full chat history for all users.

BioRouter CLI Included in Releases (macOS)

The biorouter CLI binary is now published alongside the GUI installer for macOS (both Apple Silicon and Intel). The CLI provides the same agent capabilities as the desktop app and can be used in terminal workflows, scripts, and headless environments.

Bug Fixes

  • Fixed AWS_ENDPOINT_URL_BEDROCK not being recognized by the AWS SDK; the correct AWS_ENDPOINT_URL_BEDROCK_RUNTIME is now set automatically
  • Fixed "Error Loading Sessions" on databases created before the v1.50.0 workflow rename
  • Bumped Azure default API version from 2024-10-21 to 2025-01-01-preview to support o-series reasoning models
  • Removed model IDs unavailable on UCSF proxies, eliminating confusing error messages on model selection

Upgrading

No manual migration needed. Simply replace your existing installation with the new package for your platform.

  • On macOS, replace BioRouter.app in /Applications with the new one from the DMG
  • On Linux, install the new .deb or .rpm over the existing installation (dpkg -i and rpm -U handle upgrades automatically)
  • On Windows, unzip and replace the existing installation folder

Known Limitations

  • gpt-5.4 tool use: While gpt-5.4 works via the Responses API, complex multi-tool conversations may behave differently from chat-completions models
  • Google free tier: gemini-2.5-pro and gemini-2.0-flash require a paid Google AI API plan; gemini-2.5-flash works on the free tier
  • Auto-update: Auto-update is not yet enabled; check GitHub Releases for new versions

UCSF BioRouter is developed by the Baranzini Lab at the University of California, San Francisco.
Licensed under the Apache 2.0 License.

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