v1.0

Computational models and analyses for studying proton diffusion in the TBC1D5-Rab7-NHE6 protein complex. Analysis of how protons released from NHE6 (Na+/H+ exchanger 6) diffuse through the complex to reach the pH sensor site in TBC1D5 (Rab7 GTPase-activating protein).

Supplementary material to publication

• YouJin Lee, Qing Ouyang, Li Ma, Morgan Fleishman, Hasib Aamir Riaz, Michael Schmidt, Jeffrey L. Dupree, Anupam Mondal, Priyesh Mohanty, Jeetain Mittal, Oliver Beckstein, David G. Lambright, and Eric M. Morrow. Endosome maturation is orchestrated by inside-out proton signaling through a Na⁺/H⁺ exchanger and pH-dependent Rab GTPase cycling. Nature Communications (2026) accepted.