Flabbergasted AI Skills

A curated collection of 200+ AI skills for Claude Code that extend capabilities across scientific research, software development, and creative work.

English | 中文版 | 日本語版 | Agent Guide | CLAUDE.md

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Table of Contents

• Scientific Databases
• Bioinformatics & Genomics
• Drug Discovery & Chemistry
• Machine Learning & Data Science
• Scientific Computing
• Data Visualization
• Clinical & Medical
• Scientific Writing & Publishing
• Lab Automation & Protocols
• Frontend & Web Development
• Design & Art
• Agent & Workflow
• Context Engineering
• Quantum Computing
• Document Processing

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Scientific Databases

Direct REST/SOAP API access to scientific databases for querying and downloading research data.

Skill	Description
alphafold-database	Access AlphaFold 200M+ AI-predicted protein structures
biomni	Autonomous biomedical AI agent for complex research tasks
biorxiv-database	Search life sciences preprints on bioRxiv
brenda-database	Access BRENDA enzyme database for kinetic parameters
cellxgene-census	Query CELLxGENE Census (61M+ cells) for single-cell data
chembl-database	Query ChEMBL for bioactive molecules and drug discovery data
clinicaltrials-database	Search ClinicalTrials.gov for clinical trial data
clinpgx-database	Access ClinPGx pharmacogenomics data and CPIC guidelines
clinvar-database	Query ClinVar for variant clinical significance
cosmic-database	Access COSMIC cancer mutation database
datacommons-client	Query public statistical data from Data Commons
drugbank-database	Access DrugBank for comprehensive drug information
ena-database	Access European Nucleotide Archive for sequences and reads
ensembl-database	Query Ensembl genome database for 250+ species
fda-database	Query openFDA API for drugs, devices, and adverse events
gene-database	Query NCBI Gene for gene information and annotations
geo-database	Access NCBI GEO for gene expression datasets
gwas-database	Query GWAS Catalog for SNP-trait associations
hmdb-database	Access Human Metabolome Database for metabolite data
kegg-database	Direct REST API access to KEGG pathways
metabolomics-workbench-database	Query NIH Metabolomics Workbench
openalex-database	Analyze scholarly literature via OpenAlex
opentargets-database	Query Open Targets Platform for target-disease associations
pdb-database	Access RCSB PDB for 3D protein structures
pubchem-database	Query PubChem for 110M+ compounds
pubmed-database	Direct REST API access to PubMed
reactome-database	Query Reactome for pathway analysis
string-database	Query STRING for protein-protein interactions
uniprot-database	Direct REST API access to UniProt
uspto-database	Access USPTO for patent and trademark searches
zinc-database	Access ZINC for purchasable compounds

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Bioinformatics & Genomics

Tools for analyzing biological sequences, genomics data, and single-cell omics.

Skill	Description
anndata	Data structure for annotated matrices in single-cell analysis
arboreto	Infer gene regulatory networks from expression data
biopython	Comprehensive molecular biology toolkit
bioservices	Unified Python interface to 40+ bioinformatics services
cellxgene-census	Query CELLxGENE Census for expression data
cobrapy	Constraint-based metabolic modeling and FBA
deeptools	NGS analysis toolkit for ChIP-seq, RNA-seq visualization
dnanexus-integration	DNAnexus cloud genomics platform
etetoolkit	Phylogenetic tree toolkit for phylogenomics
flowio	Parse FCS flow cytometry files
gget	Fast CLI queries to 20+ bioinformatics databases
geniml	Genomic interval machine learning for BED files
gtars	High-performance genomic interval analysis in Rust
lamindb	Open-source data framework for biology
neuropixels-analysis	Neuropixels neural recording analysis
pysam	Genomic file toolkit for SAM/BAM/VCF processing
scanpy	Standard single-cell RNA-seq analysis pipeline
scikit-bio	Biological data toolkit for sequence analysis
scvi-tools	Deep generative models for single-cell omics

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Drug Discovery & Chemistry

Molecular modeling, cheminformatics, and drug discovery workflows.

Skill	Description
adaptyv	Cloud laboratory platform for protein testing
chembl-database	Query ChEMBL for bioactive molecules
datamol	Pythonic wrapper around RDKit with simplified interface
deepchem	Molecular ML with featurizers and MoleculeNet datasets
diffdock	Diffusion-based molecular docking
drugbank-database	Access DrugBank drug information
esm	Protein language models for protein design
matchms	Spectral similarity for metabolomics
medchem	Medicinal chemistry filters (Lipinski, PAINS)
molfeat	Molecular featurization with 100+ featurizers
pymatgen	Materials science toolkit for crystal structures
pyopenms	Complete mass spectrometry analysis platform
pytdc	Therapeutics Data Commons for drug discovery datasets
rdkit	Cheminformatics toolkit for molecular analysis
torchdrug	PyTorch-native GNNs for molecules and proteins
zinc-database	Access ZINC for purchasable compounds

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Machine Learning & Data Science

ML frameworks, statistical modeling, and data science tools.

Skill	Description
aeon	Time series machine learning (classification, forecasting)
dask	Distributed computing for larger-than-RAM workflows
exploratory-data-analysis	Comprehensive EDA on200+ scientific file formats
get-available-resources	Detect system resources for computational planning
hypogenic	Automated LLM-driven hypothesis generation and testing
networkx	Complex network and graph analysis
polars	Fast in-memory DataFrame library
pydeseq2	Differential gene expression analysis
pymc	Bayesian modeling with PyMC
pymoo	Multi-objective optimization framework
pytorch-lightning	Deep learning framework with multi-GPU support
scikit-learn	Machine learning in Python
scikit-survival	Survival analysis and time-to-event modeling
shap	Model interpretability using SHAP values
stable-baselines3	Production-ready reinforcement learning
statsmodels	Statistical models library for inference
torch_geometric	Graph Neural Networks with PyG
transformers	Pre-trained transformer models (NLP, CV, audio)
umap-learn	UMAP dimensionality reduction
vaex	Out-of-core DataFrame for billion-row datasets
modal	Run Python in the cloud with serverless containers and GPUs
polars	Fast in-memory DataFrame library
pufferlib	High-performance reinforcement learning framework
pydeseq2	Differential gene expression analysis
pymc	Bayesian modeling with PyMC
pymoo	Multi-objective optimization framework
pytorch-lightning	Deep learning framework with multi-GPU support
scikit-learn	Machine learning in Python
scikit-survival	Survival analysis and time-to-event modeling
shap	Model interpretability using SHAP values
stable-baselines3	Production-ready reinforcement learning
statsmodels	Statistical models library for inference
torch_geometric	Graph Neural Networks with PyG
transformers	Pre-trained transformer models (NLP, CV, audio)
umap-learn	UMAP dimensionality reduction
vaex	Out-of-core DataFrame for billion-row datasets
zarr-python	Chunked N-D arrays for cloud storage

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Scientific Computing

Mathematical, physical, and astronomical computation tools.

Skill	Description
astropy	Python library for astronomy and astrophysics
fluidsim	Computational fluid dynamics simulations
geopandas	Geospatial vector data analysis and mapping
matlab	MATLAB and GNU Octave numerical computing
neurokit2	Biosignal processing for ECG, EEG, EDA signals
pydicom	Python library for DICOM medical imaging files
pymoo	Multi-objective optimization framework
rowan	Cloud-based quantum chemistry platform
simpy	Discrete-event simulation framework
sympy	Symbolic mathematics in Python

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Data Visualization

Plotting libraries, scientific visualization, and chart creation.

Skill	Description
matplotlib	Low-level plotting library for full customization
plotly	Interactive visualization library
scientific-schematics	Create publication-quality scientific diagrams
scientific-visualization	Publication-ready figures with journal formatting
seaborn	Statistical visualization with pandas integration

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Clinical & Medical

Healthcare AI, clinical research, and medical documentation tools.

Skill	Description
clinical-decision-support	Generate CDS documents with GRADE evidence grading
clinical-reports	Write comprehensive clinical reports
clinpgx-database	Access ClinPGx for pharmacogenomics data
clinvar-database	Query ClinVar for variant clinical significance
histolab	WSI tile extraction and preprocessing
iso-13485-certification	ISO 13485 medical device QMS documentation
omero-integration	Microscopy data management platform
pathml	Computational pathology toolkit
pyhealth	Healthcare AI for EHR and clinical prediction
treatment-plans	Generate concise medical treatment plans

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Scientific Writing & Publishing

Literature review, manuscript writing, peer review, and publication tools.

Skill	Description
citation-management	Comprehensive citation management and BibTeX
clinical-reports	Write clinical reports with regulatory compliance
doc-coauthoring	Structured workflow for co-authoring documentation
latex-posters	Create professional research posters in LaTeX
literature-review	Conduct systematic literature reviews
market-research-reports	Generate consulting-style market research reports
paper-2-web	Convert academic papers to websites and videos
peer-review	Structured manuscript/grant review
research-grants	Write competitive research proposals
research-lookup	Look up current research with Perplexity
scholar-evaluation	Evaluate scholarly work with ScholarEval framework
scientific-brainstorming	Creative research ideation
scientific-critical-thinking	Evaluate scientific claims and evidence quality
scientific-writing	Write scientific manuscripts in IMRAD structure
statistical-analysis	Guided statistical analysis with APA reporting
treatment-plans	Generate medical treatment plans
venue-templates	LaTeX templates for major publication venues

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Lab Automation & Protocols

Laboratory automation, protocol management, and experimental workflows.

Skill	Description
benchling-integration	Benchling R&D platform integration
dnanexus-integration	DNAnexus cloud genomics platform
hypogenic	Automated hypothesis testing on datasets
labarchive-integration	Electronic lab notebook API integration
latchbio-integration	Latch platform for bioinformatics workflows
omero-integration	Microscopy data management platform
opentrons-integration	Opentrons Protocol API for lab robots
protocolsio-integration	Integration with protocols.io API
pylabrobot	Vendor-agnostic lab automation framework
treatment-plans	Generate medical treatment plans

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Frontend & Web Development

UI/UX design, web development, and frontend optimization.

Skill	Description
adapt	Adapt designs for different screen sizes and platforms
amap-jsapi-skill	AMap (高德地图) JSAPI v2.0 WebGL development
animate	Enhance with animations and micro-interactions
audit	Comprehensive interface quality audit
clarify	Improve unclear UX copy and error messages
critique	Evaluate design effectiveness from UX perspective
design-principles	Apply 10 proven design principles
distill	Strip designs to their essence
frontend-design	Create production-grade frontend interfaces
harden	Improve interface resilience and error handling
json-canvas	Create and edit JSON Canvas files
mcp-builder	Create MCP servers for tool integrations
obsidian-bases	Create Obsidian Bases database views
obsidian-markdown	Create Obsidian Flavored Markdown
onboard	Design onboarding flows and empty states
optimize	Improve interface performance
polish	Final quality pass before shipping
react-best-practices	React/Next.js performance optimization
vercel-deploy-claimable	Deploy applications to Vercel
vercel-react-best-practices	Vercel React performance guidelines
vercel-react-native-skills	React Native and Expo best practices
web-artifacts-builder	Create elaborate HTML artifacts
web-design-guidelines	Review UI for Web Interface Guidelines
webapp-testing	Test web applications with Playwright

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Design & Art

Visual design, creative tools, and aesthetic enhancement.

Skill	Description
algorithmic-art	Create algorithmic art with p5.js
bolder	Amplify designs to make them more visually interesting
brand-guidelines	Apply Anthropic brand colors and typography
canvas-design	Create visual art in PNG and PDF
colorize	Add strategic color to monochromatic designs
delight	Add moments of joy and personality
extract	Extract design tokens into design system
generate-image	Generate images with AI models
normalize	Normalize design to match design system
quieter	Tone down overly bold designs
scientific-slides	Build slide decks for research talks
slack-gif-creator	Create animated GIFs for Slack
teach-impeccable	One-time setup for design context
theme-factory	Style artifacts with pre-set themes

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Agent & Workflow

Agent orchestration, workflow management, and development practices.

Skill	Description
brainstorming	Explore user intent before creative work
code-simplifier	Simplify and refine code for clarity
denario	Multiagent AI for scientific research
dispatching-parallel-agents	Handle 2+ independent tasks in parallel
doc-coauthoring	Structured workflow for co-authoring docs
executing-plans	Execute implementation plans with checkpoints
find-skills	Discover and install agent skills
finishing-a-development-branch	Guide development branch completion
git-commit	Execute git commit with intelligent staging
git-release	Create consistent releases and changelogs
hypothesis-generation	Structured hypothesis formulation
internal-comms	Write internal communications
markitdown	Convert documents to Markdown
perplexity-search	AI-powered web searches
receiving-code-review	Handle code review feedback
requesting-code-review	Request code review before merging
serenity-skill	Serenity-style investment research and thesis testing
skill-creator	Create effective skills
subagent-driven-development	Execute plans with independent tasks
systematic-debugging	Debug bugs before proposing fixes
test-driven-development	Implement features with TDD
using-git-worktrees	Create isolated git worktrees
using-superpowers	Find and use skills
verification-before-completion	Verify work before claiming completion
writing-plans	Write plans for multi-step tasks
writing-skills	Create and edit skills

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Context Engineering

AI context optimization, memory management, and agent architecture.

Skill	Description
context-compression	Compress context and reduce token usage
context-degradation	Diagnose context problems and failures
context-fundamentals	Understand context windows and architecture
context-optimization	Optimize context and reduce costs

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Quantum Computing

Quantum computing frameworks and quantum machine learning.

Skill	Description
cirq	Google quantum computing framework
pennylane	Hardware-agnostic quantum ML framework
qiskit	IBM quantum computing framework
qutip	Quantum physics simulation library

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Document Processing

File format handling, document creation, and data extraction.

Skill	Description
docx	Create and edit Word documents
markitdown	Convert files to Markdown
pdf	Comprehensive PDF manipulation
pptx	Create and edit PowerPoint presentations
pptx-posters	Create research posters in PPTX
xlsx	Create and edit Excel spreadsheets

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Skills CLI

A command-line tool for searching, installing, and managing skills. Supports installing to multiple agent tool directories at once.

Quick Start

Install from npm (recommended):

# Run directly with npx (no install needed)
npx @flabbergasted-ai/skills search "protein"
npx @flabbergasted-ai/skills install alphafold-database

# Or install globally
npm install -g @flabbergasted-ai/skills
skills search "protein"
skills install alphafold-database --target claude

Or run from the repo:

# From repo root
cd cli && npm install && cd ..

npx tsx cli/src/index.ts search "protein"
npx tsx cli/src/index.ts install alphafold-database
npx tsx cli/src/index.ts install scanpy --target claude --project

All Commands

Command	Description
search [query]	Search skills by keyword, --category, or --tag
list	List all available skills (--installed for installed only)
info <name>	Show detailed skill information
install <names...>	Install skills (--target, --path, --project)
uninstall <names...>	Uninstall skills
update [names...]	Update installed skills
outdated	Check for available updates
init <name>	Create a new skill from template
validate <path>	Validate skill directory structure
package <path>	Package skill into .skill file
config show	Show current configuration
config set <key> <value>	Set config value
config add-target <id> <path>	Add custom install target
targets	List all install targets and detection status

Install Targets

The CLI auto-detects installed agent tools and installs skills to all of them:

Target	Path	Tool
claude	~/.claude/skills/	Claude Code
cursor	~/.cursor/skills/	Cursor
agents	~/.agents/skills/	General Agent
codex	~/.codex/skills/	OpenAI Codex CLI
aider	~/.aider/skills/	Aider
continue	~/.continue/skills/	Continue.dev

Custom targets can be added via config add-target <id> <path>.

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Contributing

See CLAUDE.md for guidance on creating and modifying skills.

Updating Skills (CLI Release Not Needed)

Skills and the CLI are decoupled — the CLI fetches the skill index from GitHub CDN. Adding or updating skills does not require a CLI release.

Workflow:

# 1. Modify or add skills in public/
# 2. Rebuild the skill index
cd cli && npm run build-index

# 3. Commit and push — CDN updates automatically
git add public/ index.json
git commit -m "feat: add new-skill"
git push

Users will pick up the new skill on their next CLI invocation.

Only release a new CLI version when:

• Adding CLI features or fixing CLI bugs
• Changing the build-index.ts index generation logic

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License

See individual skill directories for license information.