Tiff Cropper v1.0
TiffCropper v1.0
First stable public release of TiffCropper, a standalone Windows application for high-resolution ROI extraction from Whole Slide Images (WSI).
Highlights
- Support for TIFF, OME-TIFF, and NDPI
- OME-TIFF export with physical size preservation
- Optional lossless DEFLATE compression
- BigTIFF output for large regions
- Pyramid-aware interactive preview
- Robust fallback strategy for partially corrupted pyramid tiles
- Fully offline executable (no Python required)
🔬 Designed for Digital Pathology Workflows
TiffCropper enables precise pixel-level cropping while preserving:
- Resolution metadata (DPI)
- Physical pixel size (µm per pixel)
- NDPI scanner metadata (embedded as OME MapAnnotations when exporting OME-TIFF)
The application handles large multi-gigapixel WSIs efficiently using block-based reading and tiled output writing.
📦 Included in this Release
TiffCropper.zip→ Windows executable packageTiffCropper_Protocol_v1.0.pdf→ Full user and technical protocol
No installation required.
Simply extract and run TiffCropper.exe.
🖥 System Requirements
- Windows 10 / 11
- ≥ 4 GB RAM (≥ 16 GB recommended for large WSI)
📜 License
MIT License
© 2026 Jose Rodriguez-Rojas