MASLD_VCTE

Reproducible analysis code, frozen configurations, public-safe derived results, figures and Source Data for:

Joint analysis of serial elastography identifies discordant attenuation and liver stiffness changes

Submission release v1.1.0

This release matches the analysis and display files prepared for submission to Clinics and Research in Hepatology and Gastroenterology on 31 July 2026.

• The primary directional-support threshold is posterior probability ≥0.60.
• A supported direction was assigned to 275 of 1,377 longitudinal pairs.
• Among supported directions, 136 were discordant (49.5%).
• The mean posterior probability of discordance across all pairs was 49.7%.
• The ≥0.70 analysis remains a high-confidence sensitivity analysis (98 supported; 43 discordant).

What this release contains

• source-data/Source_Data.xlsx: the final 86-worksheet Source Data workbook;
• figures/main/: five main figure PDFs in their final submission form;
• figures/supplementary/: eleven supplementary figure PDFs in their final submission form;
• 02_CONFIG/: frozen analysis configurations, including the ≥0.60 primary threshold;
• src/: analysis and public-data acquisition code;
• results/WP14/ and results/WP35/: privacy-safe threshold and robustness outputs;
• release-tools/: final figure assembly and Source Data update scripts;
• tests/: release-integrity, metadata and privacy checks.

No row-level local clinical data, direct identifiers, pseudonymous patient or scan identifiers, free text, exact local dates, credentials or institution- restricted extracts are included.

Clinical result represented by this release

Current liver stiffness identifies high stiffness at follow-up. Joint changes in attenuation and liver stiffness describe whether the two measurements change together or at different times. Short-interval repeat scans calibrate how much change is required before a direction is supported.

Reproducibility

Python 3.11–3.13 is supported. Install and run the release checks with:

uv sync --extra test
uv run pytest

Some end-to-end analyses require public datasets from the named repositories or governed local clinical inputs. See docs/DATA_AVAILABILITY.md and docs/REPRODUCIBILITY.md.

Citation

Please cite the archived software release using CITATION.cff. The concept DOI 10.5281/zenodo.21698541 resolves to the latest Zenodo version. The exact v1.1.0 DOI is recorded on the GitHub release page and will be added here after Zenodo completes versioning.

Authors

• Hongyu Ying (joint first author)
• Tianle Mei (joint first author)
• Chang Dong (corresponding author)
• Hong-wei Yu (corresponding author)

All are affiliated with the Department of Clinical Laboratory, Shanghai Pudong Hospital (Fudan University Pudong Medical Center), Shanghai, China.

Licensing

Code is released under the MIT License. Public-safe source data, figures, results and documentation are released under Creative Commons Attribution 4.0 International; see LICENSE-DATA.

Release: v1.1.0, 2026-07-31.