Analysis-code snapshots, non-identifying aggregate clinical results, public-data-derived molecular and spatial results, and publication figures for the manuscript “A resolver-window imbalance links stellate-cell scar occupation to liver fibrosis regression resistance.”
Stable release: v1.1.0
Repository: https://github.com/LightChainr/PathoNiche-ResolverWindow
Archived release: https://doi.org/10.5281/zenodo.21388386
The repository supports five principal findings:
- HSC-retention coupling to the scar field strengthens across human fibrosis stages.
- Retention-dominant regions enlarge and coalesce into a dominant territory.
- Interfaces between HSC-retention-dominant scar and endothelial/macrophage resolver-associated programs contract.
- Injury withdrawal follows an incomplete return trajectory in resolver–retention state space.
- The model generates an equal-exposure, order-dependent intervention hypothesis for prospective testing.
The clinical component contains only non-identifying aggregate tables from an 8,142-patient index cohort and a 772-patient longitudinal elastography cohort. No participant-level clinical record is distributed.
The full versioned release, including analysis-code snapshots, derived aggregate outputs, documentation, validation reports, and publication figures, is archived on Zenodo:
Ying H, Zhang Z, Qiao C, Dong C, Yu H-w. PathoNiche Resolver-Window: Analysis Code and Derived Data for Liver Fibrosis Regression Resistance. Version 1.1.0. Zenodo; 2026. https://doi.org/10.5281/zenodo.21388386
The GitHub repository provides the public development and issue-tracking location. The Zenodo record is the immutable archival citation for version 1.1.0.
| Level | Contents | Publicly runnable |
|---|---|---|
| A | Release validation and numerical-anchor audit | Yes, from the archived release |
| B | Derived UQ, mouse, LINCS, and aggregate clinical result inspection | Yes, from included files |
| C | Full public molecular/spatial reconstruction | Yes, after obtaining the public raw data listed in the archive |
| D | Patient-level clinical and flow analysis | No; requires institutional approval and governed source data |
Excluded material includes patient-level records, dates linked to individuals, direct or transformed clinical identifiers, linkage keys, the one-record flow–elastography linkage, ethics documents, author contact files, server credentials, raw public sequencing/imaging archives, LINCS Level 5 matrices, model weights, and manuscript drafts.
- Original analysis code: MIT License.
- Author-owned documentation, figures, and derived tabular outputs: Creative Commons Attribution 4.0 International.
- Third-party source datasets remain governed by their original terms and citation requirements.
Machine-readable citation metadata are provided in CITATION.cff and CITATION.bib.