Model snapshot and evaluation plan version 2.0

This release contains:

• the PK-Sim snapshot (*.json) file of the PBPK model (what is a "PK-Sim snapshot")
• static content (e.g. text blocks, *.md files) as inputs for an evaluation plan
• the evaluation plan (evaluation-plan.json) to create an evaluation report using the snapshot and static text blocks to display the performance of the model

The latest release of the PK-Sim project model file and the respective evaluation report can be found here.

Downloads

Fluvoxamine PK-Sim snapshot file

Fixed issues and improvements

• Evaluation plan upgraded to the latest version of the qualification plan schema (switching from the Matlab Reporting Engine to the R Reporting Engine).
• Expression profiles in the model snapshot have been consolidated.
• Observed data has been mapped to simulation outputs in the model snapshot.
• Typos fixed.

Full Changelog: v1.2...v2.0

(Alternative) model snapshot and evaluation plan version 1.0

The presented PBPK model of fluvoxamine has been developed to be used in a PBPK Drug-Drug-Interactions (DDI) network with fluvoxamine as an inhibitor of CYP2C19 and CYP1A2. This version has not been qualified for the use as CYP3A4 inhibitor.

This release contains:

• the PK-Sim snapshot (*.json) file of the PBPK model (what is a "PK-Sim snapshot")
• static content (e.g. text blocks, *.md files) as inputs for an evaluation plan
• the evaluation plan (evaluation-plan.json) to create an evaluation report using the snapshot and static text blocks to display the performance of the model
• evaluation report

Downloads

Fluvoxamine PK-Sim snapshot file
Fluvoxamine evaluation report

Fixed issues and Improvements

• Removed unused data set
• Update evaluation plan schema
• Updated titlepage to use generic versioning
• Generic versioning
• Add pk-sim project and evaluation report
• Update README.md
• All references lower case
• Typos
• Added spellcheck
• Broken Link fixes
• Remove source meta data from observed data

Model snapshot and evaluation plan version 1.2

This release contains:

• the PK-Sim snapshot (*.json) file of the PBPK model (what is a "PK-Sim snapshot")
• static content (e.g. text blocks, *.md files) as inputs for an evaluation plan
• the evaluation plan (evaluation-plan.json) to create an evaluation report using the snapshot and static text blocks to display the performance of the model

The latest release of the PK-Sim project model file and the respective evaluation report can be found here.

Downloads

Fluvoxamine PK-Sim snapshot file

Fixed issues and Improvements

• Minor bugfixes in the report (typos, broken links)

Model snapshot and evaluation plan version 1.1

This release contains:

• the PK-Sim snapshot (*.json) file of the PBPK model
• static content (e.g. text blocks, *.md files) as inputs for an evaluation plan
• the evaluation plan (evaluation-plan.json) to create an evaluation report using the snapshot and static text blocks to display the performance of the model

The latest release of the PK-Sim project model file and the respective evaluation report can be found here.

Fixed issues and Improvements

• Editorial bug fix in links to references in static text block

Model snapshot and evaluation plan version 1.0

This release contains:

• the PK-Sim snapshot (*.json) file of the PBPK model
• static content (e.g. text blocks, *.md files) as inputs for an evaluation plan
• the evaluation plan (evaluation-plan.json) to create an evaluation report using the snapshot and static text blocks to display the performance of the model

The latest release of the PK-Sim project model file and the respective evaluation report can be found here.

Downloads

Fluvoxamine PK-Sim snapshot file