Sources of Data

Resources

Molecules and How to Visualize Them
OSIRIS DataWarrior (general purpose open-source chemoinformatics software)
Google Sheet of all OSM Compounds (Can filter Series 4).
.
[http://www.cheminfo.org/flavor/malaria/Display_data.html Visualisation of OSM molecules on Cheminfo]. The data may be visualized with [http://macinchem.org/reviews/vortex/tut26/scripting_vortex26.php Vortex]. The Series 4 SDF can be generated on Cheminfo - [http://malaria.ourexperiment.org/data/files/17162/malaria-2016-05-18.sdf here] is a downloadable version from May 2016.

'''Lab Notebooks'''

[http://malaria.ourexperiment.org/triazolopyrazine_se The principal Labtrove ELN]
[https://au-mynotebook.labarchives.com/share/Edwin%2520Tse/MTYzLjh8MTUwOS8xMjYvVHJlZU5vZGUvMjUxNDEwNDEwOHw0MTUuOA== Ed Tse's Labarchives ELN]
[http://tinyurl.com/OSM-Jasper Jasper Tyler's Lab Notebook]
[https://mynotebook.labarchives.com/share/MCPHS%2520MedChem/MzUxLjB8MzY3Ny8yNzAvVHJlZU5vZGUvNDA0ODg3Njc4OHw4OTEuMA== Chase Smith's Labarchives ELN]
[http://malaria.ourexperiment.org/data/files/7384/FINAL%20REPORT%20MMV670652.doc Old document from CRO describing synthetic chemistry of some members of series]

'''Papers'''

First paper based on this series is [https://github.com/OpenSourceMalaria/OSMSeries4Paper1 being written up here]. [http://www.nature.com/nrd/journal/v15/n10/full/nrd.2016.154.html Relevant 2016 review from MMV]. [https://malariajournal.biomedcentral.com/articles/10.1186/s12936-016-1675-x 2017 New developments in anti-malarial target candidate and product profiles]

'''How To Join In'''

[https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=Series+4&milestone=&page=1&state=open The To Do List]
How to involve yourself in OSM is described in the [http://opensourcemalaria.org/ Landing Page] under "Join the Team".

'''Document Archive'''

[http://malaria.ourexperiment.org/uri/404# Initial briefing document on the series written for MMV] and a [http://malaria.ourexperiment.org/uri/406 PDF summary of pharmacokinetics and efficacy]; largely folded into the page below. (A minor error in the briefing document referring to the amides has been [http://malaria.ourexperiment.org/uri/42d clarified].)

[http://malaria.ourexperiment.org/biological_data/10041 PDF of the Compounds Originally Inherited from MMV] including structures and potencies ([http://malaria.ourexperiment.org/osdd_malaria_shared/8106/MMV_triazolopyrazine_data.html older version of this file])

[http://malaria.ourexperiment.org/osdd_malaria_shared/8292/Collected_Amides_in_the_TP_Series_Triazolopyrazines_Series_4.html Old Summary of Data on Amides in the Series]

[http://malaria.ourexperiment.org/osdd_malaria_shared/8585 ELN post containing many of the raw Chemdraw and picture files for this wiki page] - if you generate new pictures, add to the ELN page. This resource needs porting to Github.

Project Reports: [http://malaria.ourexperiment.org/osdd_malaria_shared/11335 Devon Scott and Eduvie Omene, University of Edinburgh], [https://figshare.com/articles/Developments_of_Routes_to_Access_and_Functionalise_1_2_4_Triazolo_4_3_a_pyrazine_Amides_as_New_Antimalarials/1301073/1 Tom MacDonald, The University of Sydney].

'''Online Meetings'''

[https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/386 Most recent online meeting (May 2016) relevant to this series]. [https://www.dropbox.com/s/9643p9d7mer8vfa/2016-05-24%2013.02%20Malaria%20open%20source%20drug%20discovery%20design%20meeting.mp4?dl=0 Recording].

This page is at http://tinyurl.com/OSM-Series4