Sources of Data

Resources

Molecules and How to Visualize Them

OSIRIS DataWarrior (general purpose open-source chemoinformatics software).
Google Sheet of all OSM Compounds (Can filter Series 4).
Sister sheet that explains column headings (i.e. assays used).
Visualisation of OSM molecules on Cheminfo. The data may be visualized with Vortex. The Series 4 SDF can be generated on Cheminfo - here is a downloadable version from May 2016.

'''Lab Notebooks'''

[http://malaria.ourexperiment.org/triazolopyrazine_se The principal Labtrove ELN]
[https://au-mynotebook.labarchives.com/share/Edwin%2520Tse/MTYzLjh8MTUwOS8xMjYvVHJlZU5vZGUvMjUxNDEwNDEwOHw0MTUuOA== Ed Tse's Labarchives ELN]
[http://tinyurl.com/OSM-Jasper Jasper Tyler's Lab Notebook]
[https://mynotebook.labarchives.com/share/MCPHS%2520MedChem/MzUxLjB8MzY3Ny8yNzAvVHJlZU5vZGUvNDA0ODg3Njc4OHw4OTEuMA== Chase Smith's Labarchives ELN]
[http://malaria.ourexperiment.org/data/files/7384/FINAL%20REPORT%20MMV670652.doc Old document from CRO describing synthetic chemistry of some members of series]

'''Papers'''

First paper based on this series is [https://github.com/OpenSourceMalaria/OSMSeries4Paper1 being written up here]. [http://www.nature.com/nrd/journal/v15/n10/full/nrd.2016.154.html Relevant 2016 review from MMV]. [https://malariajournal.biomedcentral.com/articles/10.1186/s12936-016-1675-x 2017 New developments in anti-malarial target candidate and product profiles]

'''How To Join In'''

[https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=Series+4&milestone=&page=1&state=open The To Do List]
How to involve yourself in OSM is described in the [http://opensourcemalaria.org/ Landing Page] under "Join the Team".

'''Document Archive'''

[http://malaria.ourexperiment.org/uri/404# Initial briefing document on the series written for MMV] and a [http://malaria.ourexperiment.org/uri/406 PDF summary of pharmacokinetics and efficacy]; largely folded into the page below. (A minor error in the briefing document referring to the amides has been [http://malaria.ourexperiment.org/uri/42d clarified].)

[http://malaria.ourexperiment.org/biological_data/10041 PDF of the Compounds Originally Inherited from MMV] including structures and potencies ([http://malaria.ourexperiment.org/osdd_malaria_shared/8106/MMV_triazolopyrazine_data.html older version of this file])

[http://malaria.ourexperiment.org/osdd_malaria_shared/8292/Collected_Amides_in_the_TP_Series_Triazolopyrazines_Series_4.html Old Summary of Data on Amides in the Series]

[http://malaria.ourexperiment.org/osdd_malaria_shared/8585 ELN post containing many of the raw Chemdraw and picture files for this wiki page] - if you generate new pictures, add to the ELN page. This resource needs porting to Github.

Project Reports: [http://malaria.ourexperiment.org/osdd_malaria_shared/11335 Devon Scott and Eduvie Omene, University of Edinburgh], [https://figshare.com/articles/Developments_of_Routes_to_Access_and_Functionalise_1_2_4_Triazolo_4_3_a_pyrazine_Amides_as_New_Antimalarials/1301073/1 Tom MacDonald, The University of Sydney].

'''Online Meetings'''

[https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/386 Most recent online meeting (May 2016) relevant to this series]. [https://www.dropbox.com/s/9643p9d7mer8vfa/2016-05-24%2013.02%20Malaria%20open%20source%20drug%20discovery%20design%20meeting.mp4?dl=0 Recording].

This page is at http://tinyurl.com/OSM-Series4