Features
uniqsketch --min-margin=N: harden signature selection against single-base sequencing errors.
With--min-margin=2,uniqsketchprefers signatures that lie at Hamming distance ≥ 2 from every
k-mer in other references, so a single substitution error in a read cannot turn a foreign k-mer into
one of a reference's signatures — a source of false-positive hits. It is a tiered preference: within
each genomic selection slot a 2-safe, non-low-complexity candidate is chosen when available, falling
back to the previous behavior only when a slot has no 2-safe option, so per-reference signature counts
and genomic spacing are preserved. A summary line reports how many selected signatures met the margin.
The default (--min-margin=1) leaves selection unchanged. Currently supports margins 1 and 2; higher
margins are planned.
Full changelog: https://github.com/amazon-science/uniqsketch/blob/main/CHANGELOG.md