Handling replicates from same time point

[elsherbini]

Does ananke handle replicates from the same time point? From reading calculate_slopes in _cluster.py it looks like it would see replicates as an issue. Would it be possible to add an option for computing the mean of samples for each time point and then proceeding?

[elsherbini]

As a follow up, is it appropriate to simply take the mean of the counts of each ASV for each time point? Will zero imputation and CLR transformation proceed with non-integer "counts"?