Skip to content

CLAIREscope v1.0.0: Initial Public Release

Choose a tag to compare

View all tags
@ccneko ccneko released this 06 Sep 14:06
· 42 commits to main since this release
v1.0.0
7bfbdf1

🔬 CLAIREscope v1.0.0 — Initial Public Release

We are excited to announce the initial public release of CLAIREscope (Single-Cell Cutaneous Landscape Analysis & Interactive Responsive Exploration platform), an open-source, high-throughput interactive visual analytics framework tailored for cutaneous biology, single-cell genomics, and multi-condition cohort comparisons.

🌟 Key Highlights & Exploration Modules

  • 🎨 Static & Interactive UMAP Studios:
    • Side-by-side comparison grids with Loupe Browser-style Log2 scaling and anchor percentile contrast thresholds.
    • Interactive 2D & 3D hardware-accelerated Plotly WebGL viewer with customizable color schemes, point density, and 3D camera controls.
  • 📊 Quantitative Cohort Analytics:
    • Sample Composition Studio: Proportional donut charts and stacked distributions with automated Fisher's exact / Chi-square test statistics.
    • Gene Expression Violins: Multi-gene distribution violins with automated non-parametric Mann-Whitney U test p-values.
    • Co-Expression & Correlation Studio: Bivariate scatter plots with linear regression, Pearson ($), and Spearman ($\rho$) correlation metrics.
  • 🧬 Functional Genomics & Dynamics:
    • Signature & Pathway Scoring Studio: Built-in score generator for custom gene sets and cutaneous biology signatures.
    • Developmental Trajectory Analysis: Diffusion Pseudotime (DPT) curves, vector trajectories, and precomputed analysis galleries.
    • Differential Expression & Volcano Plot Studio: Interactive volcano plots with customizable $\log_2\text{FC}$ and $-value cutoffs.
    • Pathway Enrichment Studio: Hypergeometric over-representation analysis against curated Gene Ontology and pathway databases.
    • Expression Heatmap Studio: Publication-grade hierarchical clustered heatmaps with Z-score standardization.
  • 🩺 Curated Cutaneous Biology Knowledgebase:
    • Integrated signature library spanning epidermal differentiation (Basal 1, Basal 2, Spinous, Granular), hair follicle compartments, fibroblast subpopulations, immune infiltrates, and wound healing cascades.
  • 💻 Desktop Integration:
    • Native 1-click desktop launcher (CLAIREscope.bat) and Python Tkinter Server Manager GUI.
  • 📜 Archival & Citation:
Assets 2
Loading