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Diffusion Kurtosis MRI (DKI) Dataset – MCI and Cognitively Normal Controls

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@data-hcp data-hcp released this 24 Mar 17:01
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Fast Kurtosis Imaging (Sequence 139) with T1-weighted MRI

This dataset provides diffusion kurtosis MRI (DKI) acquired using a fast kurtosis sequence (the 139 sequence) together with T1-weighted structural MRI from 44 patients with mild cognitive impairment (MCI) and 23 cognitively normal controls. The T1-weighted images have been skull-stripped for anonymity.

The dataset is suitable for studies of microstructural alterations in early cognitive decline and for development or benchmarking of diffusion kurtosis processing pipelines.

Dataset Overview

Participants

  • MCI patients: 44
  • Cognitively normal controls: 23
  • Total subjects: 67

Modalities

  • Diffusion kurtosis MRI (DKI)
  • T1-weighted MRI (skull-stripped)

Data Organization

  • DKI images:
    Provided as separate NIfTI files, one file per diffusion direction.

  • b-values and b-vectors:
    Stored as text files in the same folders as the diffusion images.

  • Structural MRI:
    T1-weighted images are included and have been skull-stripped to protect subject anonymity.

  • Demographics:
    Subject-level demographic information, including group identifiers, is available in demographics.csv.

This organization makes the dataset straightforward to use in custom diffusion pipelines or for conversion into other diffusion MRI formats.

Scientific Context

Please refer to the following paper for a detailed description of the study population and scientific background:

Nielsen RB, Parbo P, Ismail R, Dalby RB,
Tietze A, Brændgaard H, Gottrup H,
Brooks DJ, Østergaard L and Eskildsen SF (2025)
Diffusion kurtosis imaging detects cortical microstructural alterations in amyloid-positive MCI patients.
Front. Dement. 4:1725754.
doi: 10.3389/frdem.2025.1725754

Article link:
https://www.frontiersin.org/journals/dementia/articles/10.3389/frdem.2025.1725754/abstract

Suggested Uses

This dataset can be used for:

  • Diffusion kurtosis model fitting
  • Comparison of DKI and conventional DTI metrics
  • Studies of cortical microstructural alterations in MCI
  • Biomarker development for early cognitive impairment
  • Method development and validation for compact clinical diffusion datasets
  • Multimodal analyses combining DKI and structural MRI

License

This dataset is distributed under the:

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License (CC BY-NC-SA 4.0)

  • Attribution required
  • Non-commercial use only
  • Share alike: derivative works must use the same license

Funding

  • DFF-4004-00305

Citation

Please cite both the dataset and the associated publication:

Dataset:
Eskildsen, S.
Diffusion kurtosis MRI dataset
https://doi.org/10.6084/m9.figshare.30850301

Associated paper:
Nielsen RB, Parbo P, Ismail R, Dalby RB, Tietze A, Brændgaard H, Gottrup H, Brooks DJ, Østergaard L and Eskildsen SF (2025)
Diffusion kurtosis imaging detects cortical microstructural alterations in amyloid-positive MCI patients.
Front. Dement. 4:1725754.
https://doi.org/10.3389/frdem.2025.1725754

Notes for This Repository

The data-others/dki-mci release may include:

  • Harmonized file naming
  • Preorganized diffusion inputs for downstream processing
  • Optional DSI Studio derivatives (*.sz, *.fz)
  • QC summaries where available

Users should consult the original dataset and publication for full methodological details and cohort description.

Assets 270
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