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Harako-GPU v0.1.0-alpha.1 — Public research alpha

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@do-shima do-shima released this 21 Aug 06:27
· 4 commits to main since this release
v0.1.0-alpha.1
e533c68

Harako-GPU v0.1.0-alpha.1 release readiness

Status: public research alpha candidate. No tag, GitHub Release, Pages
deployment, container publication, or repository-visibility change is created
by this preparation branch.

Supported scope

The candidate exposes the receipt-backed Ubuntu native RTX 3090 / 128 GB host
profile, Harako-native one-pass (42.GB / 12 CPUs), Harako-native two-pass
(96.GB / 12 CPUs), fixed GRCh38.p14 / GENCODE 49 assets, Salmon 2.5.1 as the
default, and Salmon 1.10.3 as a bounded-numerical compatibility profile. The
nf-core/rnaseq 3.26 reference backend remains selectable.

Qualification summary

  • Full ERR188044 one-pass and two-pass reached terminal success with verified
    archives on the exact qualification host and assets.
  • Harako-native C1 one-pass/two-pass achieved strict scientific and BAM
    record-stream parity with the reference backend.
  • Native GUI C1 one-pass/two-pass passed the immutable product lifecycle,
    AppTest, HTTP loopback, deep verification, and sanitized support-bundle gates.
  • Salmon 2.5.1/1.10.3 C1 timing and concordance evidence has n=2 and is
    descriptive only.

Installation

Install from a fresh clone into Python 3.11+, then provision Docker/NVIDIA,
Java 17+, Nextflow 25.04.3, the exact third-party images, fixed references and
indices, and a validated host qualification receipt. Harako-GPU does not
download or redistribute Parabricks and does not accept NVIDIA terms.

Upgrade policy

Frozen runs and historical plans retain their stored workflow backend,
profiles, images, reference/index identities, and approval hashes. Never
silently migrate an analysis series across Salmon versions or workflow
backends. A later alpha may change public interfaces; review release notes and
create a new analysis series for contract changes.

Limitations and warranty

This candidate is research-only, non-diagnostic, non-clinical, and provided
without warranty. It does not qualify CPU STAR, arbitrary hosts/references,
DESeq2, matched CPU speedup, biological truth, cross-host equality, automatic
archive/delete, or production use. Actual Ubuntu browser runtime was unavailable
during GUI qualification; AppTest and HTTP qualification passed.

No Parabricks image, Docker layer, plugin binary, reference, index, FASTQ, BAM,
or third-party data asset is included in the source distribution. Third-party
licenses and terms apply independently.

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