v1.2.0-alpha.1

DNA PSSM Analyzer v1.2.0-alpha.1

First prerelease of the statistical-significance workflow.

Highlights

• Dynamic null score distributions.
• Reusable upper-tail p-values for sequence scanning.
• Benjamini–Hochberg q-values across the complete hypothesis family.
• Forward and reverse-strand scanning.
• CSV and JSON statistical exports.
• Validation against exhaustive enumeration, Biopython and SciPy.
• 77 automated tests.
• Ruff, strict mypy and CI for Python 3.10–3.12.

Important interpretation

The reported p-value is the probability, under the configured zero-order background model, of obtaining a PSSM score at least as high as the observed score.

It is not a probability of biological binding or regulatory activity.

Alpha limitations

• The public API may change before v1.2.0.
• Direct comparison against FIMO is still pending.
• A versioned real-world JASPAR validation case is still pending.
• Large genomic sequence performance has not yet been benchmarked.

DNA PSSM Analyzer v1.0.0

Primera versión estable del proyecto.

Incluye:

• Construcción de matrices PSSM.
• Lectura de secuencias FASTA.
• Cálculo de pesos log-odds.
• Información por posición.
• Escaneo de secuencias.
• Generación de logos SVG.
• Validación de entradas.
• Pruebas automáticas.