v1.5.0: independent spatial replication (W68) and dose-response (W69)

Adds the independent spatial replication (Amendment 11), the dose-response and cross-cohort analyses (Amendment 12), Fig. 7 and Supplementary Fig. S6 of the manuscript, "Cross-cohort donor-level analysis reveals a reproducible multicellular glial–vascular ALS transcriptional programme detected in astrocyte compartments".

New in v1.5.0

• docs/analysis_plans/..._AMENDMENT_11.md: replication of the motor- vs sensory-territory test in GSE288365 (Visium CytAssist cervical spinal cord with a protein panel). Fixed before any expression summary was computed.
• scripts/extract_w68_gse288365_metadata.R, build_w68_gse288365_pseudobulk.R, run_w68_replication.R, run_w68_protein_colocalisation.R: author spot annotations, donor x territory pseudobulk, territory x disease interaction (donor-blocked limma-voom; fry, camera), motor-neuron proximity, and protein co-localisation.
• docs/analysis_plans/..._AMENDMENT_12.md, scripts/run_w69_dose_response_and_combination.R: within-ALS dose-response of the motor-territory response with a motor-neuron index (with an expression-matched random-set control), and Stouffer combination of the two territory tests (post hoc summary).
• scripts/figures_v2/fig7_motor_territory.R, figS6_dose_response.R: Fig. 7 and Supplementary Fig. S6. Figs. 1 and 6 updated.
• docs/analyses/W68_*.md, docs/analyses/W69_*.md; Supplementary Tables S1-S4 updated (S4i-S4k added); README and CITATION (v1.5.0) updated.

All other scripts from v1.4.0 are unchanged. No data are included.