v1.9.0: generic-signature comparison (Amendment 15) and revised figure order

Adds Amendment 15 and the figure order of the revised manuscript, "Cross-platform validation of an ALS glial transcriptomic signature reveals a ventral-horn myeloid–glial response".

New in v1.9.0

• Amendment 15 (docs/analysis_plans/..._AMENDMENT_15.md), committed before W73 was run. It asks whether the ventral-horn response is generic neuroinflammation.
• scripts/run_w73_generic_signature_comparison.R (W73). It tests six msigdbr sets, with module genes removed, in the two territory tests: inflammatory response, TNFα–NF-κB, interferon-γ, complement, a TYROBP microglial network and an ageing-brain set. It then refits the ALS-up module with each set's score as a covariate.
  • All six programmes rise more in the ventral than the dorsal horn in ALS (combined one-sided P from 3.7 × 10⁻⁵ to 0.004).
  • The module is distinct from inflammatory, TNFα and interferon-γ signalling.
  • It partly overlaps complement and ageing programmes.
  • It is largely shared with the TYROBP network.
  • Disease specificity was not tested.
• Supplementary Tables:
  • S1: Amendment 15.
  • S2: W73 tests.
  • New sheets S4r and S4s.
• Figures.
  • Main figures renumbered to the revised Results order: Fig. 2 bulk replication, Fig. 3 ventral horn, Fig. 4 cell source with summary schematic, Fig. 5 single-nucleus reproducibility.
  • The Fig. 1 commit-timeline panel was removed.
• README and CITATION (v1.9.0) updated.

No data are included.