Analysis Tools and Code for "Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity"

This repository contains computational tools (ApobeX package) and analysis scripts for analyzing mutational signature activity, specifically APOBEC related signatures SBS2 and SBS13, within mutREAD sequencing data. MutREAD sequencing refers to a custom library preparation which samples a subset of the whole genome while retaining diversity in covered genomic positions. This method is a cost saving alternative to whole genome sequencing. We implemented a bootstrapping procedure to estimate and subtract background noise from mutational profiles.