Fluxion v5.5.6
Fluxion 5.5.6
What's New
- Crash reporting system integrated to monitor and report application crashes in real-time.
- Realistic mitochondrial membrane potential and matrix pH. The inner-membrane potential now sits in the physiological 150-190 mV range and falls as the cell works harder, rather than reading around 230 mV and climbing under load, and the matrix correctly runs about half a pH unit more alkaline than its surroundings. The guided Oxygen Supply exercise is far more accurate as a result.
- A working aerobic-to-anaerobic switch, driven by a new glycerol-3-phosphate shuttle. As oxygen is withdrawn the cell now spends phosphocreatine first, then floods with lactate as anaerobic glycolysis takes over and defends ATP -- the exact sequence the Oxygen Supply exercise is meant to teach, which the model previously could not sustain.
Improvements
- ROS balance and buffer split
- Matrix malate and the other citric-acid-cycle intermediates now hold at physiological levels during sustained exercise instead of slowly accumulating over several minutes.
Bug Fixes
- Long simulations of hard exercise or low oxygen no longer collapse to zero ATP after a few minutes; they now stay stable for a full simulated hour.
Known Issues
- Resting free phosphate reads low, from how the model divides phosphate between free phosphate, ATP, and phosphocreatine at rest.
- The mitochondrial matrix is somewhat more chemically reduced than measured (matrix NAD+/NADH sits below the textbook value).
- During prolonged oxygen-free work the modelled cell drifts slightly alkaline instead of acidifying, because exported lactate carries its acid out to the blood pool, which is not modelled as buffered.
SHA-256 checksum
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