General Preprocessing

There are some processing steps which will help to get cleaner 2D histograms. Cleaner histograms are more useful to see the fingerprints of tissues.

1. For instance skull stripping makes a noticeable difference:

(TODO: picture here, before bet) (TODO: picture here, after bet)

2. Another crucial step is to remove the intensity inhomogeneities in the data. For instance see the effect of strong inhomogeneity:

Smudged looking 2D histograms are less useful to separate the tissues.