Small coding effect refactoring and fixes#39
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…oding_effect, changing alternate start codons in M
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this does not appear to take this argument
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From a quick reading of things like 10.1126/science.1224439 and 10.1126/science.1220270 , it seems like CUG start codons will truly translate as L, whereas other cryptic start codons may initiate translation by mis-pairing with methionine tRNA's, so should be translated as M. Does that fit with what you've seen?
If that's true, it seems like this is the wrong behavior for CUG start codons (i.e. they should be left as L). Seems reasonable to also leave this as a TODO, though.
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It's unclear to me what to do with CUG since some papers also show it coding for methionine.
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Also:
...ACG, CUG, AUU, AUC, and AUA can all initiate protein synthesis to various degrees in vivo and in vitro (39). These mutant initiation codons differ from AUG by a single nucleotide. Because they use the wild-type initiator tRNA for initiation, protein synthesis in all of these cases is initiated with methionine
(http://mcb.asm.org/content/18/9/5140.full)
I think finding that CUG can initiate in vivo with a Leucine is novel but I don't know where it fits in relative to CUG methionine starts (which is more common or likely?)
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Modulo comments LGTM |
Small coding effect refactoring and fixes
2 participants
AlternateStartCodoneffect for changes like c.1ATG>TTGtranslatefunction incoding_effect