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Yes, pipx works with the current PyPI package.

pipx install --python python3.13 serena-agent
serena init

The package publishes the serena, serena-agent, and serena-hooks entry points. The main thing to watch is the Python version: the current release requires Python 3.11 through 3.14. Using --python python3.13 matches the version chosen in the quickstart instead of relying on whichever system Python pipx finds.

I also tried this with the current 1.7.0 package in a clean pipx home; the install completed and the serena CLI started normally. So unless you specifically want to follow the project's uv-based setup, pipx is fine here.

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@charger89
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@tt-a1i
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@MischaPanch
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@charger89
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Answer selected by charger89
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