What are the medicine and trade names that cannot interact with the enzyme with the product 'Heme'?
select name, trade_name from medicine except select t1.name, t1.trade_name from medicine as t1 join medicine_enzyme_interaction as t2 on t2.medicine_id = t1.id join enzyme as t3 on t3.id = t2.enzyme_id where t3.product = 'Protoporphyrinogen IX'