Interpolation with moscot

[skambha6]

Hi,

Thank you for your effort in creating this valuable tool for the community and for all of the high-quality documentation!

I was interested in applying moscot for spatiotemporal interpolation (i.e. given a time-series spatial transcriptomics dataset, with 3 timepoints [A,B,C], I would like to learn a mapping from A->C and then see if this mapping interpolates B along the way). Figure1 in the paper seems to suggest that this is a downstream analysis of moscot (attached). Is there a simple way to use the .pull() or .push() methods in the SpatioTemporalProblem class to perform this downstream task? Thank you for your help!

[MUCDK]

Hi @skambha6 ,

Thanks for your interest in moscot!

While you can find the code here, we don't recommend to use the interpolation as it doesn't work very well, and hence we don't expose the function to the user.

A much more promising approach would be https://cellflow.readthedocs.io/en/latest/notebooks/201_zebrafish_continuous.html instead (of course also depends a bit on your dataset).