Chemical biologist. I build assays at the bench and try to make helpful tools for everything around them.

As a trained biochemist, I became interested in using LLMs to build the software I need. While I am sure there is room for improvement, I would still like to make these tools open source, as they have been helpful to me. Despite using LLMs, I apply my scientific critical thinking skills to ensure that the code I produce is the best it can be by questioning everything that is produced. It's all part of the learning process, so I am happy to implement improvements in my projects. Currently, I am focusing on Monoleaf, a document editor for .md files that aims to optimise interaction with LLMs and suppress their tendency to rewrite everything. I hope this project will be helpful to others as well. It's definitely a work in progress.

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A portable, single-file Markdown editor. One .md file is the whole document: comments, tracked changes, page setup and metadata all live inside it as plain text, so there is no sidecar folder, no database and no proprietary format. It renders as you type while the file on disk stays ordinary Markdown, which also makes it safe to hand to a language model: the model marks up what it would change and you accept or reject each edit, instead of getting the whole file rewritten underneath you.

monoleaf.org  ·  Source  ·  Latest release v1.1.0  ·  7 August 2026

An open-access, crowdsourced database of fluorescent tracers for target engagement assays, so a tracer that already works for a given target can be looked up rather than rediscovered.

tracerdb.org  ·  Paper
_{Dopfer J, Vasta JD, Müller S, Knapp S, Robers MB, Schwalm MP  ·  Nature Communications 15, 5646  ·  2024}

Inhibitors supercharge kinase turnover through native proteolytic circuits
_{Scholes NS, … Schwalm MP, … Winter GE  ·  Nature 649, 1032–1041  ·  2026}

Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling
_{Schwalm MP, Knapp S  ·  SLAS Discovery 31, 100214  ·  2025}

Functional characterization of pathway inhibitors for the ubiquitin–proteasome system as tool compounds for CRBN- and VHL-mediated targeted protein degradation
_{Schwalm MP, Menge A, Elson L, Greco FA, Robers MB, Müller S, Knapp S  ·  ACS Chemical Biology 20, 94–104  ·  2025}

Luciferase- and HaloTag-based reporter assays to measure small-molecule-induced degradation pathway in living cells
_{Schwalm MP, Saxena K, Müller S, Knapp S  ·  Nature Protocols 19, 2317–2357  ·  2024}

Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
_{Schwalm MP, Krämer A, Dölle A, Weckesser J, Yu X, Jin J, Saxena K, Knapp S  ·  Cell Chemical Biology 30, 753–765  ·  2023}

PROTAC degraders as chemical probes for studying target biology and target validation
_{Nemec V, Schwalm MP, Müller S, Knapp S  ·  Chemical Society Reviews 51, 7971–7993  ·  2022}

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