MHC Ancestral Haplotypes detected in parent-child trio families from the 1KG Project
Characterizing MHC Ancestral Haplotypes from genotyping MHC loci in parent-child trio’s of the Thousand Genome Project
Ting Wang, David Sayer
Thermo Fisher Scientific, West Hills, CA, USA
- ASHI2024_poster_Wang_4117808.pdf: Poster in PDF format
- AH_*.xlsx: Supplementary tables of Ancestral Haplotypes for HLA-C to HLA-DQB1, HLA-V to HLA-DQB1, and HLA-F to HLA-DQB1 respectively
- PFB_*.xlsx: Supplementary tables of Polymorphic Frozen Block haplotypes for the MHC Alpha (HLA-V to HLA-J), Beta (HLA-C to MICA), and Delta (HLA-DRB345 to HLA-DQB1) blocks respectively
- 599 parent-child trio families from 1KGP are used. The population groups are AFR = AFRICAN (n = 603), AMR = AMERICAN (n = 405), EUR = EUROPEAN (n = 321), EAS = EAST ASIAN (n = 213), SAS = SOUTH ASIAN (n = 255).
- Ancestral Haplotype/Conserved Extended Haplotype (AH/CEH) designation is assigned if the same haplotype is identified in 3 x unrelated individuals, following the format of Degli-Esposti et al, 1992, Hum Immunol.
- OLI allele designations (eg K*OLI3) refer to novel alleles we identified in this study.
- Putative AH/CEH shaded yellow was identified in this study. Non-shaded AH/CEH was described by Cattley et al, 2000, Eur J Immunogenet.
Ting Wang (ting.wang3@thermofisher.com), David Sayer (david.sayer@thermofisher.com).