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RO:0001001 (derives into) — requires that the new entity "inherits the significant
portion of the matter of the old entity". This one fails that test. ATP's matter comes
mostly from ADP; only the phosphoryl group transfers from acetyl phosphate. So it is not
a substrate-to-product transformation in the sense the other three were.
Because it fails derives into on the ontology's own wording, it was not swept into #327
alongside the thiosulfate pair. It keeps METPO:2007800, which is why that row's subject_types still admits CHEMICAL.
Options
Re-point to the process. The real producer is the acetate kinase step, already a
node in that graph. <acetate_kinase_step> --has output--> atp (RO:0002234) is
domain-correct and true. The phosphoryl-donor role of acetyl phosphate would then want
its own edge to survive.
A phosphoryl-transfer / group-donor relation, which is what the edge is really
asserting. No obvious upstream term; would mean a METPO proposal for one edge.
Accept and document — the current state, with the reasoning recorded here and in the
mapping row.
Option 1 looks strongest and is the only one that lets METPO:2007800's subject_types
drop CHEMICAL entirely, which would make that gate exactly match its definition.
Related: #327 (the three edges that did move), #330 (the other predicate whose corpus usage
does not match its term's sense).
Examined while resolving #327 and deliberately left alone; filed so the judgement is on record.
data/traits/metabolism/acetogenesis.yamlcarries:It is the last
producesedge with aCHEMICALsubject, and it sits awkwardlybetween two relations:
METPO:2007800(produces) — defined as "the activity or state of the subjectbrings the object into existence". A chemical has neither in the agentive sense; that is
the same imprecision that moved the two thiosulfate edges in Two opposite-direction predicate labels share METPO:2000013, so one asserts the inverse of the term's meaning #327.
RO:0001001(derives into) — requires that the new entity "inherits the significantportion of the matter of the old entity". This one fails that test. ATP's matter comes
mostly from ADP; only the phosphoryl group transfers from acetyl phosphate. So it is not
a substrate-to-product transformation in the sense the other three were.
Because it fails
derives intoon the ontology's own wording, it was not swept into #327alongside the thiosulfate pair. It keeps
METPO:2007800, which is why that row'ssubject_typesstill admitsCHEMICAL.Options
node in that graph.
<acetate_kinase_step> --has output--> atp(RO:0002234) isdomain-correct and true. The phosphoryl-donor role of acetyl phosphate would then want
its own edge to survive.
asserting. No obvious upstream term; would mean a METPO proposal for one edge.
mapping row.
Option 1 looks strongest and is the only one that lets
METPO:2007800'ssubject_typesdrop
CHEMICALentirely, which would make that gate exactly match its definition.Related: #327 (the three edges that did move), #330 (the other predicate whose corpus usage
does not match its term's sense).