Pregnancy Model include renal clearance for metabolites #1794
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MSCUKW
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Hi all,
I have an issue regarding creating a pregnancy model using Pk-Sim and MoBi.
I have followed the Dallman et al., 2017 tutorial and understood that when I take my model from PK-Sim to MoBi, my renal clearance has to be added again.
In my model I have a drug, and its active metabolite; however, I am not able to re-define the renal clearance for the metabolite. I can just define it for one substance?
I tried to "add substance" and include the metabolite, but in the "Paramaters"-section I cannot specify two values or select a compound?
Does anyone know, how I can include the renal clearance for my active metabolite, too?
It would be great.
Thanks a lot!
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