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fixes for deep coverage and better QC metrics.

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@brentp brentp released this 13 Feb 16:28
· 252 commits to master since this release

v0.1.3

  • if a sample had > 1 allele that was neither REF nor ALT at a given site, it was assigned
    an unknown genotype. This was too stringent for deep sequencing so it was changed to a
    proportion (> 0.04 [or 1 in 25 alleles]) #7
  • for samples with sparse coverage, e.g. from targeted sequencing projects, mean depth is
    not very informative because it gets washed out by all the zero-depth sites. The new columns:
    gt_depth_mean, gt_depth_std, gt_depth_skew` report the values for the depth at genotyped
    sites--those meeting the depth requirement (default of 7).