Xcipion v17.11 (Chlorine 38)

• Allows fitting the same model to multiple samples
• Two-Compartments with intrinsic clearance and metabolites added
• Two-Compartments with autoinduction added
• Allometric scaling can now be estimated and applied
• Labels can be rewritten and several labels added at the same time

Xcipion v17.05 (Chlorine 32)

• Infusions are now computed more accurately
• MonoCompartment with intrinsic clearance added
• Two-Compartments with intrinsic clearance added

Xcipion v17.03 (Chlorine 30)

• Internal structure redesigned to support simultaneous intravenous and extravascular doses
• Bioavailability and lag time of drug sources can now be estimated
• Pharmacodynamics models added
• More Pharmacokinetics models added

Xcipion v16.12 (Sulphur 37)

• Administrative tasks: importing/exporting experiments, filter and join samples, filter and drop measurements, creating and merging labels, calculating cumulated dose, changing units, scaling doses
• Non-compartmental PK: fitting exponentials, calculating elimination and absorption rates, intravenous and extra-vascular NCA,
• Compartmental PK: monocompartmental (iv and ev of orders 0, 1 and mixed; iv and order 1 ev with urine data), two-compartments (iv and ev of orders 0 and 1)
• Population PK: Bootstrapping and managing populations (merging and filtering)
• Simulating any dosing regime in an individual or population
• Simulating and fitting any generic PD profile
• PBPK: Simulating the liver flow
• Statistical tests on PKPD parameters, regression, and statistical summary