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Brain and Spinal Cord Multi-Shell Diffusion MRI Dataset

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This dataset provides high-quality structural and diffusion-weighted MRI data of both the brain and cervical spinal cord from 11 healthy participants, with test–retest sessions in 6 of them.
It is organized in compliance with the Brain Imaging Data Structure (BIDS v1.9.0) and supports integrated analyses of the brain and spinal cord within the same imaging framework.

The data include multi-shell diffusion MRI (dMRI), structural (T1w, T2w, FLAIR), and spinal cord–specific contrasts (T2w, T2* mFFE), alongside a rich set of derivatives such as model fits (DTI, NODDI, SMT, SANDI), tissue and spinal cord segmentations, template registrations, and FreeSurfer reconstructions.
The dataset serves as a comprehensive multimodal resource for studying white matter microstructure, neuroanatomy, and cross-region connectivity throughout the central nervous system.

License

Creative Commons Attribution 4.0 International (CC BY 4.0)

Citation

Schilling, K. (2025).
Brain and Spinal Cord Multi-Shell Diffusion MRI Dataset [Data set].
In Characterization of neurite and soma organization in the brain and spinal cord with diffusion MRI (v1.0). Zenodo.
https://doi.org/10.5281/zenodo.15512428

Source

https://doi.org/10.5281/zenodo.15512428
Contact: kurt.schilling@vumc.org
Institution: Vanderbilt University Medical Center
Project title: Characterization of neurite and soma organization in the brain and spinal cord with diffusion MRI
Funding: Supported by multiple NIH grants (K01EB030039, R03TR004434, K01EB032898, R01NS109114, R01NS117816, R01NS104149, R01EB017230)

Dataset Information

Category Details
Subjects 11 healthy volunteers (6 with test–retest)
Study Type Multi-shell diffusion MRI of brain and cervical spinal cord
Organization BIDS v1.9.0 (brain: acq-brain; cord: acq-cord)
Imaging Sites Brain and cervical spinal cord
Data Modalities T1w, T2w, FLAIR, multi-shell DWI, mFFE (T2*)
Reverse PE Scans Included for both brain and spinal cord
Spinal Cord DWI Parts Provided as part-1, part-2, and part-3
Derived Data Preprocessed DWI, model fits (NODDI, SMT, SANDI, DTI, DKI), tissue/cord segmentations, FreeSurfer outputs
File Structure /rawdata and /derivatives directories
Data Standard Fully BIDS-compliant

Purpose

This dataset aims to support the development, validation, and benchmarking of imaging and analysis tools that unify brain and spinal cord studies.
It is especially useful for research on neurite and soma density modeling, multi-compartment diffusion imaging, and comparative neuroanatomy across central nervous system regions.
By including both structural and diffusion data for the brain and cord in the same cohort, this dataset enables cross-modality, cross-region, and test–retest investigations of tissue microstructure and connectivity.

File Information

File Description Size Checksum
Brain_Cord_MultiShell.zip Raw and derivative MRI data for all 11 subjects, organized in BIDS format 34.4 GB md5:00589b8cbf1ed17f4f6e84a62dbf886f

Keywords

Diffusion MRI • Multi-shell • Brain • Spinal Cord • SANDI • SMT • NODDI • Microstructure • BIDS • White Matter • Test–Retest

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