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linx v2.3

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@hmftools-release-bot hmftools-release-bot released this 08 Jun 21:28
· 230 commits to master since this release

Functional:

  • deletion bridge check for adjacent now considers orientation
  • somatic dup-dels in 3'UTR can be disruptive
  • fusions restored enchancer 3' upstream distance to 250K
  • set driver reported status using likelihood
  • required 1mb distance for enhancer prom fusions, check known exons if set to be high impact prom
  • highly impact exon fusions ignore chain termination and downstream distance rules
  • enhancer fusions without 3' strand can be upstream or coding, within 50K of gene
  • known fusions IG changed to enhancer, allow orientation to be 0 meaning not checked

Technical:

  • reportable vis plots use simpler naming convention
  • removed fusion fields only for patient reporter since can be derived from breakends