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OG Information Viewer
The OG Information Viewer brings together functional annotations, phylogenetic distribution, environmental expression, genome-context links, and protein-structure information for an individual SAR11 orthogroup.
Enter an orthogroup ID such as OG0000173. The autocomplete search also accepts COG IDs, KEGG Orthology (KO) IDs, Pfam accessions or names, and gene names. Select a suggestion and press Update OG Data.
After an orthogroup is loaded, the shortcut buttons open its genome-context view, neighboring-gene network, CORGIAS network, or expression profile.
The annotation header reports representative COG, KO, and Pfam assignments calculated from the current 542-genome protein annotation table. External links open the corresponding NCBI COG, KEGG, or InterPro/Pfam record.
The plots summarize how often individual annotations occur among proteins in the orthogroup:
- COG Annotation Results shows the distribution of the best COG hit assigned to each protein.
- KO Annotation Results shows the distribution of the best supported KO hit assigned to each protein.
- Pfam shows domain-level annotations and can contain multiple domains per protein.
The COG and KO pie charts include an unannotated slice when some orthogroup members lack that annotation. Pfam counts are domain/type counts and therefore should not be interpreted as mutually exclusive protein fractions.
Select a plotted annotation to open its external database record when a link is available. No Annotation or data not found means that the corresponding annotation source did not provide a supported assignment for that orthogroup.
The Taxonium panel shows presence or absence of the selected orthogroup across the default SAR11_165 IQ-TREE 2 phylogeny. The tree was rooted with 20 alphaproteobacterial outgroups and then pruned to the 542 SAR11 genomes shown in the panel. Orthogroup presence is calculated from the current 542-genome OrthoFinder assignment.
The map displays the metatranscriptomic Expression Score of the selected orthogroup across Tara Oceans samples using a log-style visual scale. The score is the sum of TPM values assigned to the OG within a sample and is not a conventional single-gene TPM measurement. Use the linked orthogroup name or Expression Profile button to open the full Metatranscriptome Viewer.
The structure panel uses the AFDB-confirmed structure-reference table generated from the 542-genome protein collection. It prioritizes close sequence matches. If an OG has no close match, a homologous reference meeting the 30% identity, 80% query coverage, 80% subject coverage, and E-value 1e-5 criteria is displayed when available. The accession is loaded into Mol*, and Open Foldseek starts a structural-homology search for that AlphaFoldDB model.
Protein sequences were searched against UniProtKB release 2026_01 with DIAMOND v2.1.10.164. Hits with at least 85% amino-acid identity were retained, and the highest-ranking hit was saved for each query protein. A UniProt match below 100% identity is not sequence-identical to the SAR11 protein.
When a homologous reference is used, the viewer warns that the model belongs to a homologous UniProt protein and is not a prediction of the SAR11 protein itself. If no confirmed reference is available, the viewer hides the empty Mol* frame and suggests AlphaFold Server when a new prediction for a specific SAR11 protein is needed.
- All OG List helps identify an orthogroup before opening this viewer.
- Neighboring Genes compares gene order around the selected orthogroup.
- Neighboring Network explores conserved neighborhood relationships.