matplotlib

matplotlib → .NET

Verdict: use what exists. Plotting is well covered in .NET.

matplotlib need	Recommended .NET
Static charts (PNG/SVG), scientific	ScottPlot — mature, fast, simple API
Interactive charts (HTML/notebook)	Plotly.NET
WPF/Avalonia integration	OxyPlot, ScottPlot.WPF/.Avalonia

dotnet add package ScottPlot

using ScottPlot;

var plot = new Plot();
plot.Add.Scatter(xs, ys);
plot.Title("Sales");
plot.SavePng("sales.png", 800, 600);

Pitfalls

• No global plt. state: ScottPlot is object-based (new Plot()), which is healthier but disorienting at first.
• Styles / themes differ from matplotlib; default palettes don't match.
• Notebooks. For interactive .NET (Polyglot Notebooks), Plotly.NET renders directly to HTML — closer to the Jupyter experience.

Guide to be expanded as real needs arise.