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MaximilianKohler edited this page Aug 9, 2019 · 5 revisions

Aging/longevity

Summary: Dysbiosis increases with age, is associated with all the diseases of old age, and seems to play a crucial role in aging itself. FMT from young donors is likely to have anti-aging effects by restoring eubiosis and reducing inflammation.

Reviews:

Review, 2018: The Gut Microbiota and Healthy Aging: A Mini-Review https://www.karger.com/Article/FullText/490615

Review, 2017: Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis: https://link.springer.com/article/10.1007/s00223-017-0345-5

Review, 2017: Gut microbiota changes in the extreme decades of human life: a focus on centenarians: https://link.springer.com/article/10.1007/s00018-017-2674-y

Review, 2017: Gut microbiota: A player in aging and a target for anti-aging intervention.

Review, 2017: The genetics of human longevity: an intricacy of genes, environment, culture and microbiome.

Review, 2016: Gut Microbiota and Extreme Longevity.

Review, 2016: Gut Instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration.

Review, 2016: Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine.

Review, 2016: Anti-Aging Effects of Probiotics.

Review, 2016: Gut Bifidobacteria Populations in Human Health and Aging: http://journal.frontiersin.org/article/10.3389/fmicb.2016.01204/full

General:

Age‐related changes in the gut microbiota influence systemic inflammation and stroke outcome [May 2018]. https://doi.org/10.1002/ana.25250 Aged biome increased the levels of systemic proinflammatory cytokines. We conclude that the gut microbiota can be modified to positively impact outcomes from age‐related diseases.

Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice (Feb 2019): https://doi.org/10.1113/JP277336

Gut Microbes Contribute to Age-Associated Inflammation in Mice. A mouse study reveals a causal link between changes in intestinal microbiota and increasing inflammation as the rodents age (2017): http://www.the-scientist.com/?articles.view/articleNo/49189/title/Gut-Microbes-Contribute-to-Age-Associated-Inflammation-in-Mice

Gut bacteria from old mice induce age-related chronic inflammation when transplanted into young mice (2017): https://www.eurekalert.org/pub_releases/2017-11/f-nlf103117.php

Study suggests age-related immune system decline is not irreversible. Fecal transplants from young mice to old mice resulted in significant improvements to the animal's gut immune system. Heterochronic faecal transplantation boosts gut germinal centres in aged mice (Jun 2019) https://newatlas.com/gut-bacteria-microbiome-aging-immune-system/59979/

Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity (2019): https://www.nature.com/articles/s41598-018-35228-3 "The physiological and immunological changes we observed in the intestine in old age, could have major consequences beyond the gut."

Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome (May 2019, mice): https://www.nature.com/articles/s41380-019-0425-1

Age-related Alterations in Microbiota-Gut-Brain Axis (2017): http://www.sciencedirect.com/science/article/pii/S088915911730034X "These changes suggest that changes in the gut microbiota and associated increases in gut permeability and peripheral inflammation may be important mediators of the impairments in behavioral, affective and cognitive functions seen in aging."

Researchers studying the gut bacteria of thousands of people around the globe have come to one conclusion: The microbiome is a surprisingly accurate biological clock, able to predict the age of most people within years https://www.sciencemag.org/news/2019/01/bacteria-your-gut-may-reveal-your-true-age - Human microbiome aging clocks based on deep learning and tandem of permutation feature importance and accumulated local effects (2018): https://doi.org/10.1101/507780

An Investigation Into Physical Frailty as a Link Between the Gut Microbiome and Cognitive Health (Dec 2018) https://www.frontiersin.org/articles/10.3389/fnagi.2018.00398/full "first human study that links cognitive performance to gut microbiome in ageing adults. highlights importance of role of physical frailty when investigating cognitive performance"

Greater Microbial Translocation & Vulnerability to Metabolic Disease in Healthy Aged Female Monkeys. (2018): https://www.nature.com/articles/s41598-018-29473-9 Ageing may lead to lower control over colonization at the mucosal surface, & reduced clearance of pathogens resulting in microbial translocation & inflammation.

We provide novel evidence that microbiota may control intestinal epithelial stem cell (IESC) proliferation in part through microRNAs (miRNAs) (2017): http://www.jbc.org/content/early/2017/01/04/jbc.M116.770099.long. Review on gut microbiota & intestinal stem cells(2017): http://journal.frontiersin.org/article/10.3389/fimmu.2017.00599/full

‘Young poo’ makes aged fish live (40%) longer. The gut microbes of young killifish can extend the lifespans of older fish – hinting at the microbiome’s role in aging (2017): http://www.nature.com/news/young-poo-makes-aged-fish-live-longer-1.21770

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction (2017): http://www.sciencedirect.com/science/article/pii/S1931312817301129. "These data suggest that aging-associated microbiota promote inflammation and that reversing these age-related microbiota changes represents a potential strategy for reducing age-associated inflammation and the accompanying morbidity."

Microbiome and Longevity: Gut Microbes Send Signals to Host Mitochondria (2017): http://www.sciencedirect.com/science/article/pii/S0092867417306414. Related article: Gut Bacteria May Help Slow Down Process of Ageing

A Tiny Tweak to Gut Bacteria Can Extend an Animal’s Life (2017): https://www.theatlantic.com/science/archive/2017/06/a-tiny-tweak-to-gut-bacteria-can-extend-an-animals-life/530364

Chemical Compound That Gives Poop Its Stink Extends Healthy Lifespan in Animals: https://gizmodo.com/chemical-compound-that-gives-poop-its-stink-extends-hea-1798156486

Microbial signatures:

Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations (Feb 2019): https://www.sciencedirect.com/science/article/pii/S0047637418302057 "Akkermansia, Alistipes, and Ruminococcoaceae D16 as signature taxa of longevity"

Age-Associated Changes in Gut Microbiota and Dietary Components Related with the Immune System in Adulthood and Old Age: A Cross-Sectional Study (July 2019) https://www.mdpi.com/2072-6643/11/8/1765/htm

Study Links Gut Microbiome With "Ridiculously Healthy" Aging (2017): https://www.psychologytoday.com/blog/the-athletes-way/201710/study-links-gut-microbiome-ridiculously-healthy-aging

Gut Microbiota and Extreme Longevity: we provide for the first time the phylogenetic microbiota analysis of semi-supercentenarians, i.e., 105–109 years old, in comparison to adults, elderly, and centenarians (2016): http://www.sciencedirect.com/science/article/pii/S0960982216303384

Gut microbiota signatures of longevity. We compare the gut microbiota of Chinese long-living people with younger age groups, and with the results from the Italian population, to identify gut-microbial signatures of healthy aging (2016): http://www.cell.com/current-biology/fulltext/S0960-9822(16)30927-7

Study by Morinaga Milk, Confirms Age-Related Changes in Human Gut Microbiota (2017): http://www.businesswire.com/news/home/20170303005206/en

Peptides:

Antimicrobial peptides extend lifespan in Drosophila.

Eco-Aging: stem cells and microbes are controlled by aging antagonist FoxO. The review highlights the dual role that the conserved master regulator FoxO has in aging by coordinating both stem cell proliferation and antimicrobial peptides, effector molecules of the innate immune system.

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